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中国环境改善下慢性阻塞性肺疾病和肺癌威胁的变化:基于以年龄为探针的模型的定量评估与预测

Changes in threats from chronic obstructive pulmonary disorder and lung cancer with environmental improvements in China: Quantitative evaluation and prediction based on a model with age as a probe.

作者信息

Hui Liu

机构信息

College of Medical Laboratory, Dalian Medical University, Dalian, 116044, China.

出版信息

Heliyon. 2024 Apr 2;10(7):e28977. doi: 10.1016/j.heliyon.2024.e28977. eCollection 2024 Apr 15.

Abstract

Various indicators can be used to assess threats from chronic diseases. This study presented new indicators of quantitative evaluation and prediction of threats from chronic obstructive pulmonary disorder (COPD) and lung cancer and assessed relevant changes in these indicators occurring with environmental improvements. Age at zero mortality (AM0) and age at average mortality (AMa) values were calculated based on the regression of the linear relationship of age with mortality for COPD or lung cancer. The lower the AM0 or AMa of a chronic disease, the greater the threats from the disease to a population were considered to be. AM0 values of both diseases were higher in 2019 than in 2004. Moreover, AM0 was lower for lung cancer than for COPD (0.365 vs. 41.643); however, lung cancer and COPD demonstrated almost identical values for age-standardized mortality. AMa values of both the diseases in 2004 and 2019 were within the range of the median age group (70-74 years). In recent years, the overall mortality risk for lung cancer and COPD has decreased with environmental improvement, and aging has played a major role in lung cancer and COPD development. AM0 and AMa values may be used as a theoretical basis for further research on chronic diseases, particularly lung cancer and COPD.

摘要

多种指标可用于评估慢性病带来的威胁。本研究提出了慢性阻塞性肺疾病(COPD)和肺癌威胁的定量评估与预测新指标,并评估了随着环境改善这些指标发生的相关变化。零死亡率年龄(AM0)和平均死亡率年龄(AMa)值是基于COPD或肺癌年龄与死亡率的线性关系回归计算得出的。一种慢性病的AM0或AMa越低,该疾病对人群的威胁就被认为越大。这两种疾病在2019年的AM0值均高于2004年。此外,肺癌的AM0低于COPD(0.365对41.643);然而,肺癌和COPD的年龄标准化死亡率值几乎相同。2004年和2019年这两种疾病的AMa值都在中位年龄组(70 - 74岁)范围内。近年来,随着环境改善,肺癌和COPD的总体死亡风险有所下降,且老龄化在肺癌和COPD的发展中起主要作用。AM0和AMa值可作为进一步研究慢性病,尤其是肺癌和COPD的理论基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/60dd/11004806/2c0ad315eb62/gr1.jpg

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