Ji Jingjing, Cheng Xi, Du Rong, Xie Yuanyuan, Zhang Yuquan
Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University, Nantong, China.
Research Central of Clinical Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Front Oncol. 2024 Mar 27;14:1364070. doi: 10.3389/fonc.2024.1364070. eCollection 2024.
Administering medication is a crucial strategy in improving the prognosis for advanced endometrial cancer. However, the rise of drug resistance often leads to the resurgence of cancer or less-than-ideal treatment outcomes. Prior studies have shown that autophagy plays a dual role in the development and progression of endometrial cancer, closely associated with drug resistance. As a result, concentrating on autophagy and its combination with medical treatments might be a novel approach to improve the prognosis for endometrial cancer. This study explores the impact of autophagy on drug resistance in endometrial cancer, investigates its core mechanisms, and scrutinizes relevant treatments aimed at autophagy, aiming to illuminate the issue of treatment resistance in advanced endometrial cancer.
给药是改善晚期子宫内膜癌预后的关键策略。然而，耐药性的增加常常导致癌症复发或治疗效果不理想。先前的研究表明，自噬在子宫内膜癌的发生和发展中起双重作用，与耐药性密切相关。因此，关注自噬及其与药物治疗的联合应用可能是改善子宫内膜癌预后的一种新方法。本研究探讨自噬对子宫内膜癌耐药性的影响，研究其核心机制，并审视针对自噬的相关治疗方法，旨在阐明晚期子宫内膜癌的治疗耐药问题。
