培氟沙星治疗由对甲氧西林敏感或耐药的金黄色葡萄球菌菌株引起的实验性心内膜炎。
Pefloxacin therapy for experimental endocarditis caused by methicillin-susceptible or methicillin-resistant strains of Staphylococcus aureus.
作者信息
Sullam P M, Täuber M G, Hackbarth C J, Chambers H F, Scott K G, Sande M A
出版信息
Antimicrob Agents Chemother. 1985 May;27(5):685-7. doi: 10.1128/AAC.27.5.685.
Abstract
The therapeutic efficacy of pefloxacin in experimental endocarditis caused by methicillin-susceptible or methicillin-resistant Staphylococcus aureus was evaluated. In rabbits infected with a methicillin-susceptible strain, 4 days of pefloxacin therapy significantly reduced both the number of bacteria per gram of vegetation and the mortality rate compared with untreated controls, and pefloxacin was equivalent to cephalothin. Pefloxacin was also as effective as vancomycin in reducing vegetation titers and mortality rate in animals with endocarditis caused by a methicillin-resistant strain. These results suggest that pefloxacin may be an effective agent in the therapy of serious infections caused by either methicillin-susceptible or -resistant strains of S. aureus.
摘要
对培氟沙星治疗由甲氧西林敏感或耐药金黄色葡萄球菌引起的实验性心内膜炎的疗效进行了评估。在感染甲氧西林敏感菌株的兔子中，与未治疗的对照组相比，4天的培氟沙星治疗显著降低了每克赘生物中的细菌数量和死亡率，且培氟沙星与头孢噻吩等效。在治疗由耐甲氧西林菌株引起的心内膜炎的动物中，培氟沙星在降低赘生物滴度和死亡率方面也与万古霉素同样有效。这些结果表明，培氟沙星可能是治疗由甲氧西林敏感或耐药金黄色葡萄球菌菌株引起的严重感染的有效药物。
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本文引用的文献
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