Laboratory of Parasitology - Mycology, Farhat Hached Hospital, Sousse, Tunisia; Department of Parasitology-Mycology, Faculty of Medicine of Sousse, University of Sousse Mohamed El Karoui Street, Bp 126,4002 Sousse, Tunisia.
Laboratory of Parasitology - Mycology, Farhat Hached Hospital, Sousse, Tunisia.
J Mycol Med. 2024 Jun;34(2):101479. doi: 10.1016/j.mycmed.2024.101479. Epub 2024 Apr 5.
With increasing concern about the negative health impact of fungal disease, there is a need to survey what is and is not known about the epidemiology of these infections in Tunisia. We have estimated the incidence and prevalence of the most serious fungal diseases in Tunisia for the first time. Using published literature from Tunisia, or if absent other countries, we have estimated the burden of life-threatening fungal infections and those causing significant morbidity, using deterministic modeling, based on populations at greatest risk. An estimated 250,494 (2.12% of the Tunisian population) are affected by a serious fungal disease annually. Invasive and chronic pulmonary aspergillosis are relatively common with 708 and 2090 patients affected, partly linked to the prevalence of chronic obstructive pulmonary disease (COPD). Fungal asthma (allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitization) have an estimated prevalence of 38,264 (5.8% of the adult asthma population). Fungal keratitis probably affects 1,761 eyes annually, often leading to uniocular blindness. Candidaemia and Candida peritonitis probably affect at least 680 people annually, with a high mortality. Recurrent vulvovaginal candidiasis probably affects over 200,000 women. While fungal diseases are regularly diagnosed in Tunisia, epidemiological studies with denominators are uncommon. Some fungal diseases are poorly addressed with the current diagnostic portfolio, and surveillance is lacking. Studies on these diseases and the implementation of a national program of surveillance are required.
随着人们对真菌病对健康的负面影响的担忧日益增加，有必要调查突尼斯对这些感染的流行病学了解程度。我们首次估计了突尼斯最严重的真菌病的发病率和患病率。我们利用来自突尼斯的已发表文献，或者在其他国家缺乏相关信息的情况下，使用基于高危人群的确定性模型，估算了危及生命的真菌感染和导致严重发病率的真菌感染的负担。估计每年有 250494 人（占突尼斯人口的 2.12%）患有严重的真菌病。侵袭性和慢性肺曲霉病相对常见，分别有 708 名和 2090 名患者受到影响，部分原因与慢性阻塞性肺疾病（COPD）的流行有关。真菌性哮喘（变应性支气管肺曲霉病和伴有真菌致敏的严重哮喘）的患病率估计为 38264 人（占成年哮喘人群的 5.8%）。真菌性角膜炎可能每年影响 1761 只眼睛，常常导致单眼失明。念珠菌血症和念珠菌性腹膜炎可能每年至少影响 680 人，死亡率较高。复发性外阴阴道念珠菌病可能影响超过 20 万名妇女。虽然真菌病在突尼斯经常被诊断出来，但很少有以基数为分母的流行病学研究。一些真菌病的诊断方法不够完善，监测也不足。需要对这些疾病进行研究，并实施国家监测计划。
