Lindsay R, Hart D M
Maturitas. 1978 Jun;1(1):21-5. doi: 10.1016/0378-5122(78)90006-3.
A double-blind crossover trial of clonidine failed to show any effect of the drug on menopausal vasomotor symptoms. A significant placebo effect was observed, the effect being greater in those with long-standing symptoms and a high neurotic index.
可乐定的双盲交叉试验未能显示该药物对更年期血管舒缩症状有任何作用。观察到显著的安慰剂效应,在症状持续时间长且神经质指数高的人群中该效应更大。