Paz G, Carmon A, Homonnai Z T
Int J Androl. 1985 Apr;8(2):139-46. doi: 10.1111/j.1365-2605.1985.tb00827.x.
The direct effect of alpha-chlorochydrin (alpha-CH) on basic metabolism (glucose utilization and oxygen consumption) and testosterone secretion by isolated rat interstitial cells (I-cells) has been studied. In the range of concentrations between 5 and 100 microliter/ml, only the highest doses of alpha-CH decreased cell vitality and their histochemical stain for 3 beta-HSD. Oxygen consumption of I-cells was depressed at all doses higher than 10 microliter/ml and this effect was reversible only with doses lower than 50 microliter/ml. glucose utilization by I-cells was depressed significantly by alpha-CH and this effect was particularly dramatic with doses higher than 50 microliter/ml. alpha-CH decreased testosterone secretion by I-cells, with maximal effects at 100 microliter/ml. I-cells responded to hCG challenge by increasing testosterone secretion, and hCG prevented the toxic effect of alpha-CH at the lowest dose (10 microliter/ml) of alpha-CH, but failed to overcome the effects of a high dose (100 microliter/ml).
研究了α-氯甘油（α-CH）对分离的大鼠间质细胞（I细胞）基础代谢（葡萄糖利用和氧消耗）以及睾酮分泌的直接影响。在5至100微升/毫升的浓度范围内，只有最高剂量的α-CH降低了细胞活力及其3β-羟类固醇脱氢酶（3β-HSD）的组织化学染色。高于10微升/毫升的所有剂量均使I细胞的氧消耗降低，且只有低于50微升/毫升的剂量这种作用才是可逆的。α-CH显著降低了I细胞对葡萄糖的利用，且高于50微升/毫升的剂量这种作用尤为明显。α-CH降低了I细胞的睾酮分泌，在100微升/毫升时作用最大。I细胞对人绒毛膜促性腺激素（hCG）刺激的反应是增加睾酮分泌，并且hCG在α-CH的最低剂量（10微升/毫升）时可预防其毒性作用，但无法克服高剂量（100微升/毫升）的影响。
