Weinreb R N, Weaver D, Mitchell M D
Invest Ophthalmol Vis Sci. 1985 Aug;26(8):1087-92.
The authors measured concentrations of prostanoids (prostaglandin-like substances) in aqueous humor from normal pigmented rabbit eyes and from those subjected to argon laser photocoagulation of the iris. The predominant prostanoids quantitatively were prostaglandin E2 (PGE2), PGF2 alpha, and PGD2 with minor amounts of 6-keto-PGF1 alpha and thromboxane B2. In all cases, concentrations of prostanoids in laser-treated eyes were substantially greater than those in normal eyes. This finding was particularly striking in the case of PGE2 which increased 60-fold from 87 pg/ml to 5.5 ng/ml after irradiation. Concentrations of prostanoids following photocoagulation were related to the number of administered laser lesions and prostanoid release was associated with an initial hypertensive response and disruption of the blood-aqueous barrier.
作者测量了正常有色兔眼以及接受虹膜氩激光光凝术的兔眼房水中类前列腺素（前列腺素样物质）的浓度。定量分析显示，主要的类前列腺素为前列腺素E2（PGE2）、前列腺素F2α（PGF2α）和前列腺素D2（PGD2），还有少量的6-酮-前列腺素F1α（6-keto-PGF1α）和血栓素B2（thromboxane B2）。在所有情况下，激光治疗眼的类前列腺素浓度显著高于正常眼。这一发现对于PGE2尤为显著，照射后其浓度从87 pg/ml增加到5.5 ng/ml，增长了60倍。光凝术后类前列腺素的浓度与所施加的激光损伤数量有关，类前列腺素的释放与最初的高血压反应以及血-房水屏障的破坏有关。
