肌肉骨骼特性的超声背向散射测量协议。
The Protocol of Ultrasonic Backscatter Measurements of Musculoskeletal Properties.
作者信息
Bi Dongsheng, Shi Lingwei, Li Boyi, Li Ying, Liu Chengcheng, Le Lawrence H, Luo Jingchun, Wang Sijia, Ta Dean
机构信息
Center for Biomedical Engineering, School of Information Science and Technology, Fudan University, 2005 Songhu Road, Yangpu District, Shanghai, 200438 China.
Academy for Engineering and Technology, Fudan University, Shanghai, 200433 China.
出版信息
Phenomics. 2023 Sep 27;4(1):72-80. doi: 10.1007/s43657-023-00122-0. eCollection 2024 Feb.
This study aims to introduce the protocol for ultrasonic backscatter measurements of musculoskeletal properties based on a novel ultrasonic backscatter bone diagnostic (UBBD) instrument. Dual-energy X-ray absorptiometry (DXA) can be adopted to measure bone mineral density (BMD) in the hip, spine, legs and the whole body. The muscle and fat mass in the legs and the whole body can be also calculated by DXA body composition analysis. Based on the proposed protocol for backscatter measurements by UBBD, ultrasonic backscatter signals can be measured in vivo, deriving three backscatter parameters [apparent integral backscatter (AIB), backscatter signal peak amplitude (BSP) and the corresponding arrival time (BSP)]. AIB may provide important diagnostic information about bone properties. BSP and BSP may be important indicators of muscle and fat properties. The standardized backscatter measurement protocol of the UBBD instrument may have the potential to evaluate musculoskeletal characteristics, providing help for promoting the application of the backscatter technique in the clinical diagnosis of musculoskeletal disorders (MSDs), such as osteoporosis and muscular atrophy.
本研究旨在介绍基于新型超声背散射骨诊断（UBBD）仪器的肌肉骨骼特性超声背散射测量方案。双能X线吸收法（DXA）可用于测量髋部、脊柱、腿部及全身的骨密度（BMD）。腿部及全身的肌肉和脂肪量也可通过DXA身体成分分析来计算。基于所提出的UBBD背散射测量方案，可在体内测量超声背散射信号，得出三个背散射参数[表观积分背散射（AIB）、背散射信号峰值幅度（BSP）及相应的到达时间（BSP）]。AIB可能提供有关骨特性的重要诊断信息。BSP和BSP可能是肌肉和脂肪特性的重要指标。UBBD仪器的标准化背散射测量方案可能有潜力评估肌肉骨骼特征，为促进背散射技术在骨质疏松症和肌肉萎缩等肌肉骨骼疾病（MSDs）临床诊断中的应用提供帮助。
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