Hoffmeister Brent K, Delahunt Sarah I, Downey Kiera L, Viano Ann M, Thomas Doni M, Georgiou Loukas A, Gray Aubrey J, Newman Will R, Main Evan N, Pirro Gia
Department of Physics, Rhodes College, Memphis, Tennessee, USA.
Department of Physics, Rhodes College, Memphis, Tennessee, USA.
Ultrasound Med Biol. 2022 Jun;48(6):997-1009. doi: 10.1016/j.ultrasmedbio.2022.01.017. Epub 2022 Mar 10.
Ultrasonic techniques are being developed to detect changes in cancellous bone caused by osteoporosis. The goal of this study was to test the relative in vivo performance of eight backscatter parameters developed over the last several years for ultrasonic bone assessment: apparent integrated backscatter (AIB), frequency slope of apparent backscatter (FSAB), frequency intercept of apparent backscatter (FIAB), normalized mean of the backscatter difference (nMBD), normalized slope of the backscatter difference (nSBD), normalized intercept of the backscatter difference (nIBD), normalized backscatter amplitude ratio (nBAR) and backscatter amplitude decay constant (BADC). Backscatter measurements were performed on the left and right femoral necks of 80 adult volunteers (age = 25 ± 11 y) using an imaging system equipped with a convex array transducer. For comparison, additional ultrasonic measurements were performed at the left and right heel using a commercially available heel-bone ultrasonometer that measured the stiffness index. Six of the eight backscatter parameters (all but nSBD and nIBD) exhibited similar and highly significant (p < 0.000001) left-right correlations (0.51 ≤ R ≤ 0.68), indicating sensitivity to naturally occurring variations in bone tissue. Left-right correlations for the stiffness index measured at the heel (R = 0.75) were not significantly better than those produced by AIB, FSAB and FIAB. The short-term precisions of AIB, nMBD, nBAR and BADC (7.8%-11.7%) were comparable to that of the stiffness index measured with the heel-bone ultrasonometer (7.5%).
超声技术正在不断发展，以检测骨质疏松症引起的松质骨变化。本研究的目的是测试过去几年开发的八个用于超声骨评估的背散射参数的相对体内性能：表观积分背散射（AIB）、表观背散射频率斜率（FSAB）、表观背散射频率截距（FIAB）、背散射差异归一化均值（nMBD）、背散射差异归一化斜率（nSBD）、背散射差异归一化截距（nIBD）、背散射幅度归一化比（nBAR）和背散射幅度衰减常数（BADC）。使用配备凸阵换能器的成像系统，对80名成年志愿者（年龄 = 25 ± 11岁）的左右股骨颈进行背散射测量。为了进行比较，使用市售的足跟骨超声仪在左右足跟进行额外的超声测量，该仪器测量硬度指数。八个背散射参数中的六个（除nSBD和nIBD外）表现出相似且高度显著（p < 0.000001）的左右相关性（0.51 ≤ R ≤ 0.68），表明对骨组织自然发生的变化具有敏感性。足跟处测量的硬度指数的左右相关性（R = 0.75）并不比AIB、FSAB和FIAB产生的相关性显著更好。AIB、nMBD、nBAR和BADC的短期精度（7.8%-11.7%）与足跟骨超声仪测量的硬度指数的精度（7.5%）相当。
