Center for Biomedical Engineering, School of Information Science and Technology, Fudan University, Shanghai, China.
State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China.
Ultrasound Med Biol. 2021 Aug;47(8):2404-2415. doi: 10.1016/j.ultrasmedbio.2021.04.002. Epub 2021 May 26.
This study aims to investigate the feasibility of quantitative ultrasonic backscatter in evaluating human cortical and trabecular bone densities in vivo based on a head-down-tilt bed rest study, with 36 participants tested through 90 d of bed rest and 180 d of recovery. Backscatter measurements were performed using an ultrasonic backscatter bone diagnostic instrument. Backscatter parameters were calculated with a dynamic signal-of-interest method, which was proposed to ensure the same ultrasonic interrogated volume in cortical and trabecular bones. The backscatter parameters exhibited significant correlations with site-matched bone densities provided by high-resolution peripheral quantitative computed tomography (0.33 < |R| < 0.72, p < 0.05). Some bone densities and backscatter parameters exhibited significant changes after the 90-d bed rest. The proposed method can be used to characterize bone densities, and the portable ultrasonic backscatter bone diagnostic device might be used to non-invasively reveal mean bone loss (across a group of people) after long-term bed rest and microgravity conditions of spaceflight missions.
本研究旨在基于头低位卧床研究，通过对 36 名参与者进行 90 天卧床和 180 天恢复期的测试，探究定量超声背散射在评估人体皮质骨和松质骨密度方面的可行性。背散射测量使用超声背散射骨诊断仪进行。背散射参数通过动态信号感兴趣方法计算得出，该方法旨在确保皮质骨和松质骨的超声探测体积相同。背散射参数与高分辨率外周定量计算机断层扫描提供的部位匹配骨密度之间具有显著相关性（0.33 < |R| < 0.72，p < 0.05）。一些骨密度和背散射参数在 90 天卧床后发生了显著变化。该方法可用于骨密度的特征描述，便携式超声背散射骨诊断仪可用于在长期卧床和太空飞行任务微重力条件下非侵入性地揭示平均骨丢失（在一群人中）。
