消化道消化过程及其生理调节机制的计算机建模：弥合消化模型与行为之间的差距。
Computer modeling of digestive processes in the alimentary tract and their physiological regulation mechanisms: closing the gap between digestion models and behavior.
作者信息
van Aken George A
机构信息
Insight Food Inside, Breda, Netherlands.
出版信息
Front Nutr. 2024 Mar 28;11:1339711. doi: 10.3389/fnut.2024.1339711. eCollection 2024.
INTRODUCTION
A model has been developed for in silico simulation of digestion and its physiological feedback mechanisms.
METHODS
The model is based on known physiology described in the literature and is able to describe the complexity of many simultaneous processes related to food digestion.
RESULTS
Despite the early stage of development of the model, it already encompasses a large number of processes that occur simultaneously, enabling the prediction of a large number of post-prandial physiological markers, which can be highly functional in combination with in vitro, organ-on-a-chip and digital twin models purposed to measure the physiological properties of organs and to predict the effect of adjusted food composition in normal and diseased states.
DISCUSSION
Input from and collaboration between science fileds is needed to further develop and refine the model and to connect with , , and (organ-on-a-chip) models.
引言
已开发出一种用于消化及其生理反馈机制的计算机模拟模型。
方法
该模型基于文献中描述的已知生理学知识，能够描述与食物消化相关的许多同时发生的过程的复杂性。
结果
尽管该模型尚处于开发早期阶段，但它已经涵盖了大量同时发生的过程，能够预测大量餐后生理标志物，这些标志物与旨在测量器官生理特性以及预测正常和疾病状态下调整食物成分效果的体外模型、芯片器官模型和数字孪生模型相结合时，可能具有很高的功能。
讨论
需要来自不同科学领域的投入和合作，以进一步开发和完善该模型，并与、和（芯片器官）模型建立联系。
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