Pakistan Institute of Medical Science, Islamabad, Pakistan.
University Hospital, Bristol and Weston NHS Foundation Trust, Royal College of Physicians and Surgeons of Glasgow, Glasgow, UK.
Medicine (Baltimore). 2024 Apr 12;103(15):e37787. doi: 10.1097/MD.0000000000037787.
Tuberculosis (TB) remains a serious problem for public health and a leading cause of death after COVID-19 and superior to even HIV/AIDS. It is a social health issue and can cause stigma and economic loss as the person cannot perform professionally due to lethargy caused by disease. It is a retrospective study done on data from National TB program Muzaffarabad chapter. The details were noted on SPSS and analysis was done to find important demographic characteristics. The total number of patients was 3441; among which 48.76% were males. Most of them (81.11%) belonged to the Muzaffarabad division of Azad Jammu and Kahmir (AJK). The microbiologically or culture positive cases were 440. Rifampicin resistance was present in 147 cases, further categorized as high (n = 143), very high (n = 3), or true positive (n = 1) resistance. Muti drug resistance was found in 19 cases. The microscopy culture is more sensitive (AUC = 0.511) than MTB/RIF or serology (AUC = 0.502) according to ROC. The rate of positive smear results is not very satisfactory in the present study as it cannot detect dormant or latent cases. There is a need to establish more sensitive tests for detection of cases and more research to combat the disease.
结核病(TB)仍然是公共卫生的严重问题,是 COVID-19 之后的主要死亡原因,甚至超过艾滋病毒/艾滋病。这是一个社会健康问题,会导致耻辱和经济损失,因为患者由于疾病导致的倦怠而无法专业地工作。这是一项在 Muzaffarabad 国家结核病计划数据上进行的回顾性研究。详细信息记录在 SPSS 上,并进行了分析以找到重要的人口统计学特征。患者总数为 3441 例;其中 48.76%为男性。他们中的大多数(81.11%)来自阿扎德查谟和克什米尔(AJK)的穆扎法尔巴德分部。微生物学或培养阳性病例为 440 例。利福平耐药性在 147 例中存在,进一步分为高(n=143)、非常高(n=3)或真实阳性(n=1)耐药性。发现 19 例耐多药。根据 ROC,显微镜培养比 MTB/RIF 或血清学更敏感(AUC=0.511)。在本研究中,阳性涂片结果的比率并不令人满意,因为它无法检测休眠或潜伏病例。需要建立更敏感的检测方法来检测病例,并进行更多的研究来对抗这种疾病。