Department of Medical Laboratory Science, Kampala International University, Kampala, Uganda.
School of Nursing Science, Kampala International University, Kampala, Uganda.
Medicine (Baltimore). 2024 Apr 12;103(15):e37695. doi: 10.1097/MD.0000000000037695.
Breastfeeding has emerged as a critical factor in understanding and potentially mitigating the risk of breast cancer among women. This review delves into the intricate relationship between breastfeeding and breast cancer, elucidating the biological mechanisms, protective effects, and broader implications for public health. Epidemiological evidence consistently demonstrates a correlation between breastfeeding and a reduced risk of breast cancer, with longer durations of lactation showing a dose-dependent decrease in risk. The biological nexus between breastfeeding and breast cancer involves hormonal changes and the elimination of potentially damaged cells, influencing breast tissue and potentially mitigating carcinogenesis. Moreover, breastfeeding appears to impact tumor subtypes and aggressiveness, particularly demonstrating associations with lower risks of hormone receptor-negative and certain aggressive breast cancer subtypes. Recognizing the significance of breastfeeding in reducing breast cancer risk has profound public health implications, necessitating comprehensive support, education, and policies to encourage and facilitate breastfeeding.
母乳喂养已成为理解和可能降低女性乳腺癌风险的关键因素。本综述深入探讨了母乳喂养与乳腺癌之间的复杂关系,阐明了其中的生物学机制、保护作用,以及对公共卫生的更广泛影响。流行病学证据一致表明,母乳喂养与乳腺癌风险降低之间存在相关性,哺乳时间越长,风险降低的程度呈剂量依赖性。母乳喂养与乳腺癌之间的生物学联系涉及激素变化和潜在受损细胞的清除,影响乳腺组织并可能抑制癌变。此外,母乳喂养似乎还影响肿瘤亚型和侵袭性,特别是与激素受体阴性和某些侵袭性乳腺癌亚型的较低风险相关。认识到母乳喂养在降低乳腺癌风险方面的重要性具有深远的公共卫生意义,需要全面的支持、教育和政策来鼓励和促进母乳喂养。