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母乳喂养及其与乳腺癌的相关性:当前的认识与成果的叙述性综述

A Narrative Review of Breastfeeding and Its Correlation With Breast Cancer: Current Understanding and Outcomes.

作者信息

Abraham Merin, Lak Muhammad Ali, Gurz Danyel, Nolasco Freida Oshin Martinez, Kondraju Preethi Kamala, Iqbal Javed

机构信息

Department of Internal Medicine, Kasturba Medical College, Manipal, IND.

Department of Internal Medicine, Combined Military Hospital, Lahore, PAK.

出版信息

Cureus. 2023 Aug 25;15(8):e44081. doi: 10.7759/cureus.44081. eCollection 2023 Aug.

DOI:10.7759/cureus.44081
PMID:37750138
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10518059/
Abstract

Breastfeeding has been extensively studied in relation to breast cancer risk. The results of the reviewed studies consistently show a decreased risk of breast cancer associated with breastfeeding, especially for 12 months or longer. This protective effect is attributed to hormonal, immunological, and physiological changes during lactation. Breastfeeding also appears to have a greater impact on reducing breast cancer risk in premenopausal women and specific breast cancer subtypes. Encouraging breastfeeding has dual benefits: benefiting infants and reducing breast cancer risk long-term. Healthcare professionals should provide evidence-based guidance on breastfeeding initiation, duration, and exclusivity, while public health policies should support breastfeeding by creating enabling environments. This review examines the existing literature and analyzes the correlation between breastfeeding and breast cancer risk.

摘要

关于母乳喂养与乳腺癌风险的关系已进行了广泛研究。所综述研究的结果一致表明,母乳喂养与降低乳腺癌风险相关,尤其是母乳喂养12个月及以上时。这种保护作用归因于哺乳期的激素、免疫和生理变化。母乳喂养似乎对降低绝经前女性及特定乳腺癌亚型的乳腺癌风险有更大影响。鼓励母乳喂养有双重益处:有益于婴儿并长期降低乳腺癌风险。医疗保健专业人员应就母乳喂养的开始、持续时间和纯母乳喂养提供循证指导,而公共卫生政策应通过创造有利环境来支持母乳喂养。本综述审视了现有文献并分析了母乳喂养与乳腺癌风险之间的相关性。

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A Narrative Review of Breastfeeding and Its Correlation With Breast Cancer: Current Understanding and Outcomes.母乳喂养及其与乳腺癌的相关性:当前的认识与成果的叙述性综述
Cureus. 2023 Aug 25;15(8):e44081. doi: 10.7759/cureus.44081. eCollection 2023 Aug.
2
Breast cancer, pregnancy, and breastfeeding.乳腺癌、妊娠与母乳喂养。
J Obstet Gynaecol Can. 2002 Feb;24(2):164-80; quiz 181-4.
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Exploring the profound link: Breastfeeding's impact on alleviating the burden of breast cancer - A review.探讨深远关联:母乳喂养缓解乳腺癌负担的影响——综述。
Medicine (Baltimore). 2024 Apr 12;103(15):e37695. doi: 10.1097/MD.0000000000037695.
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A systematic review of structured versus non-structured breastfeeding programmes to support the initiation and duration of exclusive breastfeeding in acute and primary healthcare settings.一项关于结构化与非结构化母乳喂养计划的系统评价,以支持在急性和初级卫生保健环境中开始并持续进行纯母乳喂养。
JBI Libr Syst Rev. 2011;9(36):1471-1508. doi: 10.11124/01938924-201109360-00001.
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Stud Fam Plann. 1993 Sep-Oct;24(5):295-309.
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Breast-feeding and family planning: a review of the relationships between breast-feeding and family planning.母乳喂养与计划生育:母乳喂养与计划生育关系的综述
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J Hum Lact. 2019 Feb;35(1):100-113. doi: 10.1177/0890334418765464. Epub 2018 Jun 21.
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A systematic review to evaluate the effectiveness of interventions to promote the initiation of breastfeeding.一项评估促进母乳喂养启动干预措施有效性的系统评价。
Health Technol Assess. 2000;4(25):1-171.
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Interventions for supporting the initiation and continuation of breastfeeding among women who are overweight or obese.针对超重或肥胖女性的支持母乳喂养启动和持续进行的干预措施。
Cochrane Database Syst Rev. 2019 Sep 17;9(9):CD012099. doi: 10.1002/14651858.CD012099.pub2.

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Breast Cancer Res. 2025 May 1;27(1):67. doi: 10.1186/s13058-025-02031-8.
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Pharmacophore modeling and molecular dynamics simulations to study the conformational stability of natural HER2 inhibitors in breast cancer therapy.用于研究天然HER2抑制剂在乳腺癌治疗中构象稳定性的药效团建模与分子动力学模拟
Mol Divers. 2025 Mar 24. doi: 10.1007/s11030-025-11165-y.
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The Impact of an Educational Project on Cancer-Related Knowledge and Awareness Among High School Students.一个教育项目对高中生癌症相关知识和认知的影响
J Cancer Educ. 2025 Mar 18. doi: 10.1007/s13187-025-02604-3.
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The Relationship Between Nursing Work Environment and Breastfeeding Prevalence During Child Hospitalization: A Multicenter Study.儿童医院住院期间护理工作环境与母乳喂养率的关系:一项多中心研究
Healthcare (Basel). 2024 Dec 21;12(24):2574. doi: 10.3390/healthcare12242574.
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Breast J. 2024 Sep 21;2024:1987378. doi: 10.1155/2024/1987378. eCollection 2024.
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Epigenetic and Immune Mechanisms Linking Breastfeeding to Lower Breast Cancer Rates.母乳喂养与较低乳腺癌发病率相关的表观遗传和免疫机制。
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Beyond Milk and Nurture: Breastfeeding's Powerful Impact on Breast Cancer.超越乳汁与养育:母乳喂养对乳腺癌的强大影响
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Am J Perinatol. 2024 Dec;41(16):2243-2251. doi: 10.1055/s-0044-1786546. Epub 2024 May 9.

本文引用的文献

1
Innovations and Challenges in Breast Cancer Care: A Review.乳腺癌护理的创新与挑战:综述
Medicina (Kaunas). 2023 May 16;59(5):957. doi: 10.3390/medicina59050957.
2
Patients' perceived challenges, competencies, and supportive care needs during acute clinical treatment of breast or gynecological cancer.患者在急性乳腺癌或妇科癌症临床治疗期间的感知挑战、能力和支持性护理需求。
Psychooncology. 2023 May;32(5):682-691. doi: 10.1002/pon.6112. Epub 2023 Feb 22.
3
Support for healthy breastfeeding mothers with healthy term babies.支持健康足月婴儿的母乳喂养母亲。
Cochrane Database Syst Rev. 2022 Oct 25;10(10):CD001141. doi: 10.1002/14651858.CD001141.pub6.
4
Breastfeeding reduces the risk of breast cancer: A call for action in high-income countries with low rates of breastfeeding.母乳喂养可降低乳腺癌风险:呼吁在母乳喂养率低的高收入国家采取行动。
Cancer Med. 2023 Feb;12(4):4616-4625. doi: 10.1002/cam4.5288. Epub 2022 Sep 26.
5
Current and future burden of breast cancer: Global statistics for 2020 and 2040.乳腺癌的现状和未来负担:2020 年和 2040 年全球统计数据。
Breast. 2022 Dec;66:15-23. doi: 10.1016/j.breast.2022.08.010. Epub 2022 Sep 2.
6
The Risk Factors, Incidence and Prognosis of Postpartum Breast Cancer: A Nationwide Study by the SMARTSHIP Group.产后乳腺癌的危险因素、发病率及预后:SMARTSHIP 组的一项全国性研究
Front Oncol. 2022 Jul 1;12:889433. doi: 10.3389/fonc.2022.889433. eCollection 2022.
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Challenges and opportunities for breast cancer early detection among rural dwelling women in Segamat District, Malaysia: A qualitative study.马来西亚士古来区农村女性乳腺癌早期检测的挑战与机遇:一项定性研究。
PLoS One. 2022 May 20;17(5):e0267308. doi: 10.1371/journal.pone.0267308. eCollection 2022.
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Global challenges in breast cancer detection and treatment.乳腺癌检测和治疗的全球挑战。
Breast. 2022 Mar;62 Suppl 1(Suppl 1):S3-S6. doi: 10.1016/j.breast.2022.02.003. Epub 2022 Feb 8.
9
Factors influencing exclusive breastfeeding rates until 6 months postpartum: the Japan Environment and Children's Study.影响产后 6 个月内纯母乳喂养率的因素:日本环境与儿童研究。
Sci Rep. 2021 Mar 25;11(1):6841. doi: 10.1038/s41598-021-85900-4.
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Breastfeeding Challenges: ACOG Committee Opinion, Number 820.母乳喂养挑战:ACOG 委员会意见,第 820 号。
Obstet Gynecol. 2021 Feb 1;137(2):e42-e53. doi: 10.1097/AOG.0000000000004253.