Facultad de Medicina, Universidad de Zaragoza, Spain.
Servicio de Bioquímica, Hospital Universitario "Lozano Blesa", Zaragoza, Spain; Insitututo de Investigación Sanitaria de Aaragón, España.
Rev Clin Esp (Barc). 2024 May;224(5):253-258. doi: 10.1016/j.rceng.2024.04.006. Epub 2024 Apr 10.
The SERPINA1 gene encodes the protein Alpha-1 Antitrypsin (AAT1). Possible imbalances between the concentrations of proteases and antiproteases (AAT1) can lead to the development of serious pulmonary and extrapulmonary pathologies. In this work we study the importance of this possible imbalance in patients with COVID-19.
To correlate the severity of the symptoms of SARS-COV-2 infection with the AAT1 concentrations at diagnosis of the disease.
An observational, prospective, cross-sectional, non-interventional, analytical study was carried out where 181 cases with COVID-19 admitted to the "Lozano Blesa" University Clinical Hospital of Zaragoza were selected. The concentration of AAT1 was studied in all of them and this was correlated with the clinical aspects and biochemical parameters at hospital admission.
141 cases corresponded to patients with severe COVID and 40 patients with mild COVID. AAT1 levels were positively correlated with the days of hospitalization, severity, C-Reactive Protein, ferritin, admission to Intensive Care, and death, and presented a negative correlation with the number of lymphocytes/mm3. AAT1 concentrations higher than 237.5 mg/dL allowed the patient to be classified as "severe" (S72%; E78%) and 311.5 mg/dL were associated with the risk of admission to Intensive Care or Exitus (S67%; E79%).
Levels of the SERPINA1 gene expression product, AAT1, correlate with the severity of COVID-19 patients at diagnosis of the disease, being useful as a prognostic biomarker.
SERPINA1 基因编码 Alpha-1 抗胰蛋白酶（AAT1）蛋白。蛋白酶和抗蛋白酶（AAT1）之间浓度的可能失衡可能导致严重的肺外和肺外病理发生。在这项工作中，我们研究了这种可能失衡在 COVID-19 患者中的重要性。
将 SARS-COV-2 感染症状的严重程度与疾病诊断时的 AAT1 浓度相关联。
进行了一项观察性、前瞻性、横断面、非干预性、分析性研究，从中选择了 181 例入住萨拉戈萨“洛萨诺·布莱萨”大学临床医院的 COVID-19 患者。对所有人都研究了 AAT1 的浓度，并将其与入院时的临床方面和生化参数相关联。
141 例患者对应于严重 COVID 患者，40 例患者对应于轻度 COVID 患者。AAT1 水平与住院天数、严重程度、C 反应蛋白、铁蛋白、入住重症监护病房和死亡呈正相关，与淋巴细胞/mm3 的数量呈负相关。AAT1 浓度高于 237.5 mg/dL 可将患者归类为“严重”（S72%；E78%），而 311.5 mg/dL 与入住重症监护病房或死亡的风险相关（S67%；E79%）。
SERPINA1 基因表达产物 AAT1 的水平与 COVID-19 患者疾病诊断时的严重程度相关，可用作预后生物标志物。
