Yeditepe University, Faculty of Health Sciences, Department of Nutrition and Dietetics, İstanbul, Turkey.
Yeditepe University, Faculty of Medicine, Department of Histology and Embryology, İstanbul, Turkey.
Prostaglandins Other Lipid Mediat. 2024 Aug;173:106837. doi: 10.1016/j.prostaglandins.2024.106837. Epub 2024 Apr 10.
Pomegranate seed oil shows positive effects by limiting neutrophil activation and lipid peroxidation through its antioxidant and anti-inflammatory activities. This study evaluated the possible ameliorative effects of pomegranate seed oil, its actions on proinflammatory cytokines, and its antioxidant activity using an acute acetic acid-induced colitis model in rats. 32 male Sprague-Dawley rats were divided into 4 groups: control, colitis, 0.4 ml/kg, and 0.8 ml/kg pomegranate seed oil treatment after colitis. At the end of the experiment, histopathological and biochemical analyses of intestinal tissues and blood were performed. The study revealed that administering different doses of pomegranate seed oil dramatically reduced total oxidant levels, nuclear factor kappa B, proinflammatory cytokines, and myeloperoxidase activity and appreciably reduced colitis injury. These findings suggest that pomegranate seed oil may alleviate colitis symptoms effectively and exert protective effects through antioxidant, anti-inflammatory mechanisms.
石榴籽油通过其抗氧化和抗炎活性，通过限制中性粒细胞的激活和脂质过氧化，显示出积极的效果。本研究使用大鼠急性乙酸诱导结肠炎模型，评估了石榴籽油的可能改善作用、其对促炎细胞因子的作用及其抗氧化活性。32 只雄性 Sprague-Dawley 大鼠分为 4 组：对照组、结肠炎组、结肠炎后给予 0.4ml/kg 和 0.8ml/kg 石榴籽油治疗组。实验结束时，对肠道组织和血液进行组织病理学和生化分析。研究表明，给予不同剂量的石榴籽油可显著降低总氧化剂水平、核因子 kappa B、促炎细胞因子和髓过氧化物酶活性，并可显著减轻结肠炎损伤。这些发现表明，石榴籽油可能通过抗氧化、抗炎机制有效缓解结肠炎症状并发挥保护作用。
