College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao 266071, China.
College of Chemistry and Chemical Engineering, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao 266071, China; State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao 266071, China; School of Materials Science and Engineering, Shandong University of Technology, Zibo 255000, China.
Int J Biol Macromol. 2024 May;267(Pt 2):131494. doi: 10.1016/j.ijbiomac.2024.131494. Epub 2024 Apr 10.
Transcatheter arterial embolization (TACE) has been used in the treatment of malignant tumors, sudden hemorrhage, uterine fibroids, and other diseases, and with advances in imaging techniques and devices, materials science, and drug release technology, more and more embolic agents that are drug-carrying, self-imaging, or have multiple functions are being developed. Microspheres provide safer and more effective therapeutic results as embolic agents, with their unique spherical appearance and good embolic properties. Embolic microspheres are the key to arterial embolization, blocking blood flow and nutrient supply to the tumor target. This review summarizes some of the currently published embolic microspheres, classifies embolic microspheres according to matrix, and summarizes the characteristics of the microsphere materials, the current status of research, directions, and the value of existing and potential applications. It provides a direction to promote the development of embolic microspheres towards multifunctionalization, and provides a reference to promote the research and application of embolic microspheres in the treatment of tumors.
经导管动脉栓塞术（TACE）已被应用于治疗恶性肿瘤、突发性出血、子宫肌瘤等疾病，随着成像技术和设备、材料科学以及药物释放技术的进步，越来越多的载药、自显影或具有多种功能的栓塞剂正在被开发。微球作为栓塞剂具有更安全、更有效的治疗效果，其独特的球形外观和良好的栓塞性能。栓塞微球是动脉栓塞的关键，可阻断肿瘤靶区的血流和营养供应。本文综述了一些已发表的栓塞微球，根据基质对栓塞微球进行分类，并总结了微球材料的特性、研究现状、方向以及现有和潜在应用的价值。为推动栓塞微球向多功能化发展提供了方向，并为促进栓塞微球在肿瘤治疗中的研究和应用提供了参考。
