产气荚膜梭菌致肠道上皮细胞损伤的机制。

Mechanisms of intestinal epithelial cell damage by Clostridiumperfringens.

机构信息

Key Laboratory of Livestock Disease Prevention of Guangdong Province, Key Laboratory of Avian Influenza and Other Major Poultry Diseases Prevention and Control, Ministry of Agriculture and Rural Affairs, Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou, 510640, China; College of Life Science and Engineering, Foshan University, Foshan, 528225, China.

出版信息

Anaerobe. 2024 Jun;87:102856. doi: 10.1016/j.anaerobe.2024.102856. Epub 2024 Apr 10.

DOI:10.1016/j.anaerobe.2024.102856

PMID:38609034

Abstract

Clostridium perfringens, a Gram-positive bacterium, causes intestinal diseases in humans and livestock through its toxins, related to alpha toxin (CPA), beta toxin (CPB), C. perfringens enterotoxin (CPE), epsilon toxin (ETX), Iota toxin (ITX), and necrotic enteritis B-like toxin (NetB). These toxins disrupt intestinal barrier, leading to various cell death mechanisms such as necrosis, apoptosis, and necroptosis. Additionally, non-toxin factors like adhesins and degradative enzymes contribute to virulence by enhancing colonization and survival of C. perfringens. A vicious cycle of intestinal barrier breach, misregulated cell death, and subsequent inflammation is at the heart of chronic inflammatory and infectious gastrointestinal diseases. Understanding these mechanisms is essential for developing targeted therapies against C. perfringens-associated intestinal diseases.

摘要

产气荚膜梭菌是一种革兰氏阳性细菌，其通过相关的α毒素（CPA）、β毒素（CPB）、产气荚膜梭菌肠毒素（CPE）、ε毒素（ETX）、ι毒素（ITX）和坏死性肠炎 B 样毒素（NetB）引发人类和家畜的肠道疾病。这些毒素破坏肠道屏障，导致各种细胞死亡机制，如坏死、凋亡和坏死性凋亡。此外，黏附素和降解酶等非毒素因素通过增强产气荚膜梭菌的定植和存活来增强其毒力。肠道屏障破坏、细胞死亡失调以及随后的炎症的恶性循环是慢性炎症性和感染性胃肠道疾病的核心。了解这些机制对于开发针对产气荚膜梭菌相关肠道疾病的靶向治疗方法至关重要。