Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, PourSina St., Qods St., Enghelab St., Tehran, 141761315, Iran.
Department of Environmental Health Engineering, Faculty of Health and Nutrition, Bushehr University of Medical Sciences, Bushehr, Iran.
Sci Rep. 2024 Apr 12;14(1):8562. doi: 10.1038/s41598-024-59308-9.
This study investigated the association between serum concentrations of Polychlorinated Biphenyls (PCBs) and the risk of type 2 diabetes within the general population. A ten-year follow-up historical cohort study was conducted during 2009-2019 as part of the Bushehr MONICA cohort study in Iran. Of 893 non-diabetes participants at base line, 181 individuals were included in the study. The concentration of nine PCB congeners was measured in individuals' serum samples at baseline, and the risk of type 2 diabetes was determined based on fasting blood sugar at the end of follow-up. Multiple logistic regression models were used to assess the study outcomes after adjusting for covariates. This study included 59 diabetes individuals (32.6%; mean [SD] age: 58.64 [8.05]) and 122 non-diabetes individuals (67.4%; mean [SD] age: 52.75 [8.68]). Multivariable analysis revealed that a one-tertile increase (increasing from 33rd centile to 67th centile) in Σ non-dioxin-like-PCBs (OR 2.749, 95% CI 1.066-7.089), Σ dioxin-like-PCBs (OR 4.842, 95% CI 1.911-12.269), and Σ PCBs (OR 2.887, 95% CI 1.120-7.441) significantly associated with an increased risk of type 2 diabetes. The strongest association was obtained for dioxin-like PCBs. The results highlight a significant correlation between PCB exposure and an increased risk of type 2 diabetes. The evidence suggests that additional epidemiological studies are necessary to clarify the link between PCBs and diabetes.
本研究旨在探讨人群血清多氯联苯（PCBs）浓度与 2 型糖尿病风险之间的关联。这是一项为期 10 年的随访历史队列研究，作为伊朗布什尔 MONICA 队列研究的一部分，于 2009 年至 2019 年进行。在基线时，共有 893 名非糖尿病参与者，其中 181 人纳入本研究。在基线时测量了个体血清样本中 9 种 PCB 同系物的浓度，并根据随访结束时的空腹血糖来确定 2 型糖尿病的风险。使用多变量逻辑回归模型来调整协变量后评估研究结果。本研究纳入了 59 名糖尿病患者（32.6%；平均[SD]年龄：58.64 [8.05]）和 122 名非糖尿病患者（67.4%；平均[SD]年龄：52.75 [8.68]）。多变量分析显示，Σ非二恶英样 PCBs（OR 2.749，95%CI 1.066-7.089）、Σ二恶英样 PCBs（OR 4.842，95%CI 1.911-12.269）和 ΣPCBs（OR 2.887，95%CI 1.120-7.441）每增加一个四分位距（从第 33 百分位增加到第 67 百分位）与 2 型糖尿病风险增加显著相关。二恶英样 PCBs 的相关性最强。结果表明，PCBs 暴露与 2 型糖尿病风险增加之间存在显著相关性。有证据表明，需要开展更多的流行病学研究来阐明 PCBs 与糖尿病之间的联系。
