Cork University Dental School & Hospital, Wilton, Cork, Ireland.
University College Cork, Wilton, Cork, Ireland.
BMC Oral Health. 2024 Apr 12;24(1):446. doi: 10.1186/s12903-024-04227-4.
Oral health impacts systemic health, individual well-being, and quality of life. It is important to identify conditions that may exacerbate oral disease to aid public health and policy development and promote targeted patient treatment strategies. Developmental defects can increase an individual's risk of dental caries, hypersensitivity, premature tooth wear, erosion, and poor aesthetics. As part of an ongoing study assessing oral health in adults with cystic fibrosis at Cork University Dental School and Hospital, a systematic review of available literature was conducted to assess the prevalence of enamel defects in people with cystic fibrosis.
To critically evaluate the literature to determine if the prevalence of developmental defects of enamel is higher in people with cystic fibrosis (PwCF).
Data Sources: Three online databases were searched Embase, Scopus, and Web of Science Core Collection. Studies that examined an association between cystic fibrosis and developmental defects of enamel were included in this systematic review.
The initial search identified 116 publications from the following databases Embase, Web of Science Core Collection, and Scopus. Eleven studies were included for qualitative analysis. Nine studies concluded that PwCF had a higher prevalence of enamel defects than control people and one study found no difference in cystic fibrosis (CF) status. All studies had a risk of bias that may influence study results and their interpretation.
The results of the systematic review show a consistent pattern that PwCF have a higher prevalence of DDE than people without CF. Genetic dysfunction, chronic systemic infections, and long-term antibiotic use are possible aetiological causes. This review highlights the need for future studies to investigate if DDEs are caused by the underlying CFTR mutation or as a consequence of disease manifestations and/or management.
口腔健康影响全身健康、个体幸福感和生活质量。确定可能使口腔疾病恶化的情况对于促进公共卫生和政策制定以及促进有针对性的患者治疗策略非常重要。发育缺陷会增加个体患龋齿、过敏、牙齿过早磨损、侵蚀和美观不佳的风险。作为科克大学牙科学院和医院评估囊性纤维化成人口腔健康的正在进行的研究的一部分，对现有文献进行了系统回顾，以评估囊性纤维化患者牙釉质缺陷的患病率。
批判性评估文献，以确定囊性纤维化患者（PwCF）的牙釉质发育缺陷的患病率是否更高。
数据来源：在 Embase、Scopus 和 Web of Science Core Collection 这三个在线数据库中进行了搜索。纳入了检查囊性纤维化与牙釉质发育缺陷之间关联的研究。
初步搜索从以下数据库 Embase、Web of Science Core Collection 和 Scopus 中确定了 116 篇出版物。有 11 项研究纳入定性分析。九项研究得出结论，PwCF 牙釉质缺陷的患病率高于对照组，一项研究发现囊性纤维化（CF）状况无差异。所有研究都存在可能影响研究结果及其解释的偏倚风险。
系统评价的结果显示出一致的模式，即 PwCF 比没有 CF 的人有更高的 DDE 患病率。遗传功能障碍、慢性全身感染和长期使用抗生素可能是病因。这篇综述强调了未来研究需要调查 DDE 是否是由潜在的 CFTR 突变引起的，还是由疾病表现和/或治疗引起的。
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