Ferrazzano G F, Sangianantoni G, Cantile T, Amato I, Orlando S, Ingenito A
Department of Paediatric Dentistry, University of Naples Federico II, Naples, Italy.
Community Dent Health. 2012 Mar;29(1):106-9.
The relationship between cystic fibrosis (CF) and caries experience has already been explored, but relatively little information is available on dental enamel defects prevalence among children affected by cystic fibrosis. The aim of this study was to investigate this issue in deciduous and permanent teeth of children with CF resident in southern Italy.
This cross sectional observational study was undertaken between October 2009 and March 2010.
88 CF patients and 101 healthy age-matched participated in this study.
The prevalence of dental enamel defects was calculated using a modified Developmental Defects of Enamel (DDE) index. The comparison of dental enamel defects prevalence among groups was carried out using regression binary logistic analysis.
In the CF subjects there was a higher prevalence (56%) of enamel defects in comparison to the healthy group (22%). The most prevalent enamel defect was hypoplasia with loss of enamel (23% of CF patients vs 1 1/2% of control group) in permanent teeth.
This study confirms that children with cystic fibrosis are at increased risk of developing hypoplastic defects on their permanent teeth.
囊性纤维化（CF）与龋齿经历之间的关系已得到探讨，但关于受囊性纤维化影响儿童的牙釉质缺陷患病率的信息相对较少。本研究的目的是调查意大利南部患有CF的儿童乳牙和恒牙中的这一问题。
本横断面观察性研究于2009年10月至2010年3月进行。
88名CF患者和101名年龄匹配的健康人参与了本研究。
使用改良的牙釉质发育缺陷（DDE）指数计算牙釉质缺陷的患病率。采用二元逻辑回归分析对各组牙釉质缺陷患病率进行比较。
与健康组（22%）相比，CF受试者牙釉质缺陷的患病率更高（56%）。恒牙中最常见的牙釉质缺陷是牙釉质发育不全伴牙釉质缺失（CF患者为23%，对照组为1.5%）。
本研究证实，患有囊性纤维化的儿童恒牙出现发育不全缺陷的风险增加。
