吡柔比星治疗急性早幼粒细胞白血病

THP-ADM in the treatment of acute promyelocytic leukemia.

作者信息

Uzuka Y, Saito Y

出版信息

Tohoku J Exp Med. 1985 May;146(1):1-8. doi: 10.1620/tjem.146.1.

DOI:10.1620/tjem.146.1

Abstract

Three patients, diagnosed as acute promyelocytic leukemia and disseminated intravascular coagulation (DIC), were treated with THP-ADM in combination with heparin and intensive platelet transfusion. Two of the three patients achieved complete remission. The remaining one patient also responded favorably to the therapy and achieved marrow aplasia, and significant improvement of coagulopathy was observed after chemotherapy. However, he suddenly died of intractable congestive cardiac disturbance ten days after the completion of THP-ADM induction therapy. The mechanism of this unique delayed anthracycline-associated cardiotoxicity was discussed.

摘要

三名被诊断为急性早幼粒细胞白血病并伴有弥散性血管内凝血（DIC）的患者，接受了吡柔比星（THP-ADM）联合肝素及强化血小板输注的治疗。三名患者中有两名实现了完全缓解。其余一名患者对该治疗也有良好反应，出现了骨髓抑制，化疗后凝血障碍有显著改善。然而，在吡柔比星诱导治疗结束十天后，他突然死于难治性充血性心脏功能紊乱。文中讨论了这种独特的迟发性蒽环类药物相关心脏毒性的机制。