Krzesłowska Wiktoria Julia, Woźniacka Anna
Department of Dermatology and Venereology, Medical University of Lodz, Hallera 1, 90-647 Lodz, Poland.
J Clin Med. 2024 Apr 7;13(7):2137. doi: 10.3390/jcm13072137.
Frontal fibrosing alopecia (FFA) is a type of cicatricial alopecia predominantly observed in postmenopausal women, with the incidence rising since its initial description in 1994. The exact etiopathogenesis of the disease has not been completely elucidated. FFA is characterized by an inflammatory process affecting the hair follicles of the fronto-temporal hairline, leading to its gradual recession. Eyebrows, particularly the lateral parts, may also be affected. Early diagnosis and an implementation of effective therapy to limit the inflammatory process are crucial in halting disease progression. Various treatment possibilities have been reported, including anti-inflammatory and immunosuppressive agents, as well as 5-alpha-reductase inhibitors, retinoids, and antimalarial agents. The use of phototherapy and surgical procedures has also been described. However, most available data have been obtained retrospectively, frequently consisting of descriptions of case reports or small case series, and not from randomized controlled trials. In addition, the etiopathogenesis of FFA remains unclear and its course unpredictable, occasionally being linked with spontaneous stabilization. Hence, no precise guidelines exist regarding treatment modalities. Therefore, the aims of this study were to provide a comprehensive review of the efficacy of existing therapeutic modalities for FFA and to highlight novel therapeutic options.
额部纤维性秃发（FFA）是一种瘢痕性秃发，主要见于绝经后女性，自1994年首次描述以来发病率不断上升。该病的确切病因尚未完全阐明。FFA的特征是炎症过程累及额颞发际线的毛囊，导致其逐渐后移。眉毛，尤其是外侧部分，也可能受到影响。早期诊断并实施有效的治疗以限制炎症过程对于阻止疾病进展至关重要。已经报道了各种治疗方法，包括抗炎和免疫抑制剂，以及5-α还原酶抑制剂、维甲酸和抗疟药。光疗和外科手术的应用也有描述。然而，大多数现有数据都是回顾性获得的，通常是病例报告或小病例系列的描述，而非来自随机对照试验。此外，FFA的病因仍不清楚，其病程不可预测，偶尔会与自发稳定相关。因此，关于治疗方式没有确切的指南。因此，本研究的目的是全面综述现有FFA治疗方式的疗效，并突出新的治疗选择。
