Ponomareva T V, Merkushev G N, Ivanov E V, Bisenieks E A, Dubur G Ia
Arkh Anat Gistol Embriol. 1985 May;88(5):66-71.
By means of light and electron microscopy, intracellular reparation has been studied after a local x-ray radiation of the rat paws (7.74 X 10(-1) Ci/kg) using radioprotectors (mexamin, cysteamin, ionol) and other chemical compounds (including membranoprotective ones). Restoration of the intracellular structures after x-ray burns proceeds more slowly and more complexly than reparation of the epidermis as a tissue system. To the slowly repairing intracellular formations belong mitochondria and, especially, internal mitochondrial membrane, as well as intercellular contacts. Under radiation mitochondria increase their volume at the expense of their three-fold swelling. Preliminary treatment of the skin with some of the compounds mentioned above decreases or completely prevents these changes. By means of the membranoactive chemical compounds, as well as by means of the known radioprotectors it is possible essentially to normalize the process of intracellular reparation and physiological regeneration of the ultrastructures, and in some cases, to stimulate reparative processes in them.
通过光学显微镜和电子显微镜，利用辐射防护剂（美克昔明、半胱胺、生育酚）及其他化合物（包括膜保护化合物），对大鼠爪子进行局部X射线辐射（7.74×10⁻¹居里/千克）后，研究了细胞内修复情况。X射线烧伤后细胞内结构的恢复比作为组织系统的表皮修复更为缓慢和复杂。修复缓慢的细胞内结构包括线粒体，尤其是线粒体内膜，以及细胞间连接。在辐射下，线粒体通过三倍肿胀来增加其体积。用上述某些化合物对皮肤进行预处理可减少或完全防止这些变化。借助膜活性化合物以及已知的辐射防护剂，基本上可以使细胞内修复过程和超微结构的生理再生正常化，在某些情况下，还能刺激其中的修复过程。
