Ashmarin I P
Zh Evol Biokhim Fiziol. 1979 May-Jun;15(3):278-82.
Probable peculiarities of evolution of neurotransmitters (NM) and neuromodulators (NR) of various types are discussed. The hypothesis of higher evolutionary rate of peptide NM and NR, and of more diverse possibilities of the formation of this type of NM and NR is suggested. Monomolecular MN and NR are presumably more conservative, although they exhibit some advantage with respect to strict differentiation of the systems of synthesis and degradation. Probably, the most ancient NM and NR are presented by such compounds as peptides, some amino acids, and ATP.
本文讨论了不同类型神经递质（NM）和神经调质（NR）可能的进化特性。提出了肽类NM和NR具有更高进化速率以及形成这类NM和NR有更多样化可能性的假说。单分子MN和NR可能更为保守，尽管它们在合成和降解系统的严格区分方面具有一些优势。可能，最古老的NM和NR是由肽、某些氨基酸和ATP等化合物构成的。
