Ashmarin I P
Neurosci Behav Physiol. 1982 Mar-Apr;12(2):177-81. doi: 10.1007/BF01189330.
The probable features of the evolution of neuromediators (NM) and neuromodulators (NR) of different types are discussed. The assumption concerning the high rate of evolution of peptide NM and NR and the greater potentialities of the formation of new NM and NR of this type is substantiated. Monomolecular NM and NR are presumably more conservative, but have an advantage as regards the strict individualism of the systems of synthesis and degradation. Peptides, individual amino acids, and ATP are probably among the oldest NM and NR.
讨论了不同类型神经介质（NM）和神经调质（NR）进化的可能特征。关于肽类NM和NR进化速度快以及形成此类新NM和NR的潜力更大的假设得到了证实。单分子NM和NR可能更保守，但在合成和降解系统的严格个体性方面具有优势。肽、单个氨基酸和ATP可能是最古老的NM和NR之一。
