Zorn S H, Enna S J
Brain Res. 1985 Jul 15;338(2):380-3. doi: 10.1016/0006-8993(85)90173-8.
The antinociceptive responses to the gamma-aminobutyric acid receptor agonists THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-3-ol) and baclofen were examined in spinally transected mice to define the central nervous system site of action for these drugs. Nociception was assessed using a tail-immersion assay. The results indicated that spinal transection (T6-T10) completely abolished the antinociceptive responses to THIP and baclofen, attenuated those to oxotremorine and morphine, but did not reduce the response to clonidine. The results suggest that the antinociceptive responses to THIP and baclofen are mediated by an action at supraspinal sites rostral to T6.
在脊髓横断的小鼠中检测了对γ-氨基丁酸受体激动剂THIP（4,5,6,7-四氢异恶唑并[5,4-c]吡啶-3-醇）和巴氯芬的抗伤害感受反应，以确定这些药物的中枢神经系统作用部位。使用尾部浸入试验评估伤害感受。结果表明，脊髓横断（T6-T10）完全消除了对THIP和巴氯芬的抗伤害感受反应，减弱了对氧震颤素和吗啡的反应，但并未降低对可乐定的反应。结果表明，对THIP和巴氯芬的抗伤害感受反应是由T6以上的脊髓上部位的作用介导的。
