用去甲丙咪嗪反复处理的大鼠对巴氯芬和4,5,6,7-四氢异恶唑并（5,4-c）吡啶-3-醇（THIP）的功能反应
Functional responses to baclofen and 4,5,6,7-tetrahydroisoxazolo (5,4-c) pyridin-3-ol (THIP) in rats repeatedly treated with desipramine.
作者信息
Borsini F, Giuliani S, Meli A
机构信息
A. Menarini s.a.s., Research Division, Firenze, Italia.
出版信息
Pharmacol Biochem Behav. 1988 Jan;29(1):189-91. doi: 10.1016/0091-3057(88)90294-8.
PMID:3353425
Abstract
Subcutaneous chronic desipramine (DMI, 5 mg/kg once daily for 18 consecutive days) prevented subcutaneous THIP (20 mg/kg) reduction in body temperature but did not affect THIP behavioral depressant effect (open-field behavior). Repeated DMI treatment did not affect subcutaneous baclofen (2.5-10 mg/kg) reduction in body temperature and behavioral depression (open-field behavior).
摘要
皮下注射慢性给予去甲丙咪嗪（DMI，5毫克/千克，每日一次，连续18天）可防止皮下注射THIP（20毫克/千克）引起的体温降低，但不影响THIP的行为抑制作用（旷场行为）。重复给予DMI治疗不影响皮下注射巴氯芬（2.5 - 10毫克/千克）引起的体温降低和行为抑制（旷场行为）。
Zotero 插件