Global Health and Tropical Medicine, GHTM, Associate Laboratory in Translation and Innovation Towards Global Health, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, UNL, Rua da Junqueira 100, 1349-008 Lisbon, Portugal.
Centre for Interdisciplinary Research in Animal Health, CIISA, Faculty of Veterinary Medicine, FMV, University of Lisbon, ULisboa, 1649-004 Lisbon, Portugal.
Int J Mol Sci. 2024 Mar 29;25(7):3840. doi: 10.3390/ijms25073840.
Chagas disease (CD) is a vector-borne Neglected Zoonotic Disease (NZD) caused by a flagellate protozoan, , that affects various mammalian species across America, including humans and domestic animals. However, due to an increase in population movements and new routes of transmission, infection is presently considered a worldwide health concern, no longer restricted to endemic countries. Dogs play a major role in the domestic cycle by acting very efficiently as reservoirs and allowing the perpetuation of parasite transmission in endemic areas. Despite the significant progress made in recent years, still there is no vaccine against human and animal disease, there are few drugs available for the treatment of human CD, and there is no standard protocol for the treatment of canine CD. In this review, we highlight human and canine Chagas Disease in its different dimensions and interconnections. Dogs, which are considered to be the most important peridomestic reservoir and sentinel for the transmission of infection in a community, develop CD that is clinically similar to human CD. Therefore, an integrative approach, based on the One Health concept, bringing together the advances in genomics, immunology, and epidemiology can lead to the effective development of vaccines, new treatments, and innovative control strategies to tackle CD.
恰加斯病（CD）是一种由鞭毛原生动物引起的媒介传播的被忽视的人畜共患疾病（NZD），影响美洲的各种哺乳动物，包括人类和家畜。然而，由于人口流动的增加和新的传播途径，感染现在被认为是一个全球性的健康问题，不再局限于流行国家。狗在家庭循环中起着重要的作用，因为它们作为储存宿主非常有效，并允许寄生虫在流行地区的传播持续下去。尽管近年来取得了重大进展，但仍没有针对人和动物疾病的疫苗，只有少数几种药物可用于治疗人类 CD，而且也没有治疗犬 CD 的标准方案。在这篇综述中，我们强调了人类和犬恰加斯病在其不同方面和相互联系。狗被认为是最重要的家庭周围储存宿主和传播感染的哨点，它们会患上与人类 CD 临床相似的疾病。因此，基于“同一健康”概念的综合方法，结合基因组学、免疫学和流行病学的进展，可以有效地开发疫苗、新的治疗方法和创新的控制策略来应对 CD。
