State Key Laboratory of Grassland Agro-Ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou 730000, China.
College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
Int J Mol Sci. 2024 Mar 31;25(7):3896. doi: 10.3390/ijms25073896.
Colorectal cancer (CRC) is a serious global health concern, and researchers have been investigating different strategies to prevent, treat, or support conventional therapies for CRC. This review article comprehensively covers CRC therapy involving wild-type bacteria, including probiotics and oncolytic bacteria as well as genetically modified bacteria. Given the close relationship between CRC and the gut microbiota, it is crucial to compile and present a comprehensive overview of bacterial therapies used in the context of colorectal cancer. It is evident that the use of native and engineered probiotics for colorectal cancer therapy necessitates research focused on enhancing the therapeutic properties of probiotic strains.. Genetically engineered probiotics might be designed to produce particular molecules or to target cancer cells more effectively and cure CRC patients.
结直肠癌（CRC）是一个严重的全球健康问题，研究人员一直在探索不同的策略来预防、治疗或支持结直肠癌的常规疗法。这篇综述文章全面涵盖了涉及野生型细菌的 CRC 治疗，包括益生菌和溶瘤细菌以及基因修饰细菌。鉴于 CRC 与肠道微生物群之间的密切关系，有必要综合和呈现用于结直肠癌的细菌治疗的全面概述。显然，使用天然和工程益生菌治疗结直肠癌需要专注于增强益生菌菌株的治疗特性的研究。。基因工程益生菌可以设计用于产生特定的分子，或者更有效地靶向癌细胞，从而治愈 CRC 患者。
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