Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610064, PR China; Laboratory of Clinical Pharmacy and Adverse Drug Reaction, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610064, PR China.
Adv Drug Deliv Rev. 2022 Jun;185:114295. doi: 10.1016/j.addr.2022.114295. Epub 2022 Apr 13.
The clinical application of bacteria-mediated immune therapy dates back over a century ago. In recent years, these strategies have advanced greatly with the rapid development of synthetic biology and nanotechnology. Several bacterial therapies have been developed allowing for more effective treatments for cancers, and Salmonella is one of the most studied bacterial species. Here, we review the advances in the bioengineered and functionalized Salmonella Typhimurium strains as drug delivery carries, including the various genetic circuits for programing these bacteria, the surface modification strategies using nanoparticles or other therapeutic agents for richer and broader features, and the bacterial component-based vehicles for cancer immunotherapy. This review will include the promises and challenges of these optimized Salmonella-based delivery systems and their related clinical trials. Ultimately, we hope to provide a spark of thought in the field of drug delivery and find important crosstalk between bacteria-mediated therapy and other different forms of treatments.
细菌介导的免疫疗法的临床应用可以追溯到一个多世纪以前。近年来，随着合成生物学和纳米技术的飞速发展，这些策略有了很大的进步。已经开发出几种细菌疗法，使癌症的治疗更加有效，而沙门氏菌是研究最多的细菌物种之一。在这里，我们回顾了作为药物输送载体的生物工程和功能化鼠伤寒沙门氏菌菌株的进展，包括用于编程这些细菌的各种遗传回路、使用纳米粒子或其他治疗剂进行表面修饰的策略，以及基于细菌成分的癌症免疫疗法载体。本综述将包括这些优化的基于沙门氏菌的递药系统的前景和挑战，以及它们相关的临床试验。最终，我们希望能为药物输送领域提供一些启示，并在细菌介导的治疗与其他不同形式的治疗之间找到重要的交叉点。
