Immunology and Transplant Immunology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Centre of Immunogenetics and Virology, Fundeni Clinical Institute, 022328 Bucharest, Romania.
Int J Mol Sci. 2024 Apr 8;25(7):4120. doi: 10.3390/ijms25074120.
The Golgi apparatus, long recognized for its roles in protein processing and vesicular trafficking, has recently been identified as a crucial contributor to innate immune signaling pathways. This review discusses our expanding understanding of the Golgi apparatus's involvement in initiating and activating these pathways. It highlights the significance of membrane connections between the Golgi and other organelles, such as the endoplasmic reticulum, mitochondria, endosomes, and autophagosomes. These connections are vital for the efficient transmission of innate immune signals and the activation of effector responses. Furthermore, the article delves into the Golgi apparatus's roles in key immune pathways, including the inflammasome-mediated activation of caspase-1, the -STING pathway, and TLR/RLR signaling. Overall, this review aims to provide insights into the multifunctional nature of the Golgi apparatus and its impact on innate immunity.
高尔基器，长期以来因其在蛋白质加工和小泡运输中的作用而为人所知，最近被确定为先天免疫信号通路的关键贡献者。本文讨论了我们对高尔基器参与启动和激活这些通路的理解的不断扩展。它强调了高尔基器与其他细胞器（如内质网、线粒体、内体和自噬体）之间膜连接的重要性。这些连接对于先天免疫信号的有效传递和效应器反应的激活至关重要。此外，本文还探讨了高尔基器在关键免疫途径中的作用，包括炎症小体介导的半胱天冬酶-1激活、-STING 途径和 TLR/RLR 信号转导。总的来说，本文旨在深入了解高尔基器的多功能性质及其对先天免疫的影响。
