高尔基体蛋白 73 在肝脏疾病中的可能作用。
Possible roles of Golgi protein-73 in liver diseases.
机构信息
Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University; Medical College, China Three Gorges University; Institute of Organ Fibrosis and Targeted Drug Delivery, China Three Gorges University, Yichang, China.
Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
出版信息
Ann Hepatol. 2022 Sep-Oct;27(5):100720. doi: 10.1016/j.aohep.2022.100720. Epub 2022 May 14.
Golgi protein 73 (also known as GP73 or GOLPH2) is a transmembrane glycoprotein present in the Golgi apparatus. In diseased states, GP73 is expressed by hepatocytes rather than by bile duct epithelial cells. Many studies have reported that serum GP73 (sGP73) is a marker for hepatocellular carcinoma (HCC). For HCC diagnosis, the sensitivities of sGP73 were higher than that of other markers but the specificities were lower. Considering that the concentration of GP73 is consistent with the stage of liver fibrosis and cirrhosis, some studies have implied that GP73 may be a marker for liver fibrosis and cirrhosis. Increased sGP73 levels may result from hepatic inflammatory activity. During liver inflammation, GP73 facilitates liver tissue regeneration. By summarizing the studies on GP73 in liver diseases, we wish to focus on the mechanism of GP73 in diseases.
高尔基体蛋白 73（也称为 GP73 或 GOLPH2）是一种存在于高尔基体中的跨膜糖蛋白。在疾病状态下，GP73 由肝细胞表达，而不是由胆管上皮细胞表达。许多研究报告称，血清 GP73（sGP73）是肝细胞癌（HCC）的标志物。对于 HCC 诊断，sGP73 的灵敏度高于其他标志物，但特异性较低。考虑到 GP73 的浓度与肝纤维化和肝硬化的阶段一致，一些研究表明 GP73 可能是肝纤维化和肝硬化的标志物。sGP73 水平的升高可能是由于肝炎症活动引起的。在肝炎症期间，GP73 促进肝组织再生。通过总结肝脏疾病中关于 GP73 的研究，我们希望关注 GP73 在疾病中的作用机制。
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