Dietetics and Nutrition Technology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur 176061, Himachal Pradesh, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Dietetics and Nutrition Technology Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur 176061, Himachal Pradesh, India.
Biotechnol Adv. 2024 Jul-Aug;73:108362. doi: 10.1016/j.biotechadv.2024.108362. Epub 2024 Apr 12.
Oral thin films (OTFs) are innovative dosage forms that have gained tremendous attention for the delivery of nutraceuticals. They are ultra-thin, flexible sheets that can be easily placed on the tongue, sublingual or buccal mucosa (inner lining of the cheek). These thin films possess several advantages for nutraceutical delivery including ease of administration, rapid disintegration, fast absorption, rapid onset of action, bypass first-pass hepatic metabolism, accurate dosing, enhanced stability, portability, discreetness, dose flexibility and most importantly consumer acceptance. This review highlights the utilization OTFs for nutraceutical delivery, their composition, criteria for excipient selection, methods of development and quality-based design (QbD) approach to achieve quality product. We have also provided recent case studies representing OTFs as promising platform in delivery of nutraceuticals (plant extracts, bioactive molecules, vitamins, minerals and protein/peptides) and probiotics. Finally, we provided advancement in technologies, recent patents, market analysis, challenges and future perspectives associated with this unique dosage form.
口腔薄膜（OTFs）是一种创新的剂型，因其能够传递营养保健品而备受关注。它们是超薄、柔韧的薄片，可以轻松地放在舌头上、舌下或颊黏膜（脸颊的内层）上。这些薄膜在营养保健品传递方面具有多个优势，包括易于给药、快速崩解、快速吸收、快速起效、绕过首过肝脏代谢、准确剂量、增强稳定性、便携性、隐蔽性、剂量灵活性，最重要的是消费者接受度。这篇综述强调了 OTFs 在营养保健品传递中的应用，包括它们的组成、辅料选择标准、开发方法和基于质量的设计（QbD）方法，以实现高质量的产品。我们还提供了最近的案例研究，代表 OTFs 作为传递营养保健品（植物提取物、生物活性分子、维生素、矿物质和蛋白质/肽）和益生菌的有前途的平台。最后，我们提供了与这种独特剂型相关的技术进展、最新专利、市场分析、挑战和未来展望。
