Liang Zhaohuang, Zhang Yao, Li Guoyue
Department of General Dentistry and Integrated Emergency Dental Care, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing, China.
J Dent Sci. 2024 Apr;19(2):1012-1020. doi: 10.1016/j.jds.2023.06.026. Epub 2023 Jul 11.
BACKGROUND/PURPOSE: The relationship between Vitamin D (VD) and periodontitis in patients with metabolic syndrome (MetS) was unclear. This study was to investigate the relationship between VD and periodontitis in MetS patients.
This cross-sectional study collected the data of 2165 MetS patients from the National Health and Nutrition Examination Survey (NHANES). The weighted univariate and multivariable Logistic regression models were applied to identify covariates and evaluate the association between 25-hydroxy vitamin D (25(OH)D) [25(OH)D] + 25(OH)D and periodontitis in patients. Odds ratio (OR) [95% confidence interval (CI)] was effect size. Subgroup analysis was performed in people with or without diabetes, dyslipidemia, hypertension, cardiovascular disease (CVD) and central obesity groups.
In the unadjusted model, compared with patients with 25(OH)D + 25(OH)D < 50 nmol/L, those with 25(OH)D + 25(OH)D ≥ 50 nmol/L might be associated with decreased risk of periodontitis in MetS patients (OR = 0.70, 95% CI: 0.57-0.85). After adjusting for confounders including age, gender, race, education, poverty income ratio (PIR), smoking, diabetes, VD intake and supplement and number of missing teeth, 25(OH)D + 25(OH)D ≥ 50 nmol/L was correlated with reduced risk of periodontitis in MetS patients (OR = 0.76, 95% CI: 0.60-0.97). Subgroup analysis revealed that in patients with CVD (OR = 0.60, 95% CI: 0.37-0.98), dyslipidemia (OR = 0.75, 95% CI: 0.57-0.97), and patients with central obesity (OR = 0.73, 95% CI: 0.57-0.95), decreased risk of periodontitis was identified in 25(OH)D + 25(OH)D ≥ 50 nmol/L.
VD was associated with the risk of periodontitis in patients with MetS, which suggest the importance of VD supplement in patients with MetS and provide a reference for the management of periodontitis in patients with MetS.
背景/目的：代谢综合征（MetS）患者中维生素D（VD）与牙周炎之间的关系尚不清楚。本研究旨在调查MetS患者中VD与牙周炎之间的关系。
这项横断面研究收集了来自美国国家健康与营养检查调查（NHANES）的2165例MetS患者的数据。应用加权单变量和多变量逻辑回归模型来识别协变量，并评估25-羟基维生素D（25(OH)D）[25(OH)D] + 25(OH)D与患者牙周炎之间的关联。比值比（OR）[95%置信区间（CI）]为效应量。在有或没有糖尿病、血脂异常、高血压、心血管疾病（CVD）和中心性肥胖组的人群中进行亚组分析。
在未调整模型中，与25(OH)D + 25(OH)D < 50 nmol/L的患者相比，25(OH)D + 25(OH)D≥50 nmol/L的患者MetS患者患牙周炎的风险可能降低（OR = 0.70，95% CI：0.57 - 0.85）。在调整了包括年龄、性别、种族、教育程度、贫困收入比（PIR）、吸烟、糖尿病、VD摄入和补充以及缺失牙数量等混杂因素后，25(OH)D + 25(OH)D≥50 nmol/L与MetS患者患牙周炎风险降低相关（OR = 0.76，95% CI：0.60 - 0.97）。亚组分析显示，在患有CVD（OR = 0.60，95% CI：0.37 - 0.98）、血脂异常（OR = 0.75，95% CI：0.57 - 0.97）以及中心性肥胖患者（OR = 0.73，95% CI：0.57 - 0.95）中，25(OH)D + 25(OH)D≥50 nmol/L可降低患牙周炎的风险。
VD与MetS患者患牙周炎的风险相关，这表明补充VD在MetS患者中的重要性，并为MetS患者牙周炎的管理提供参考。
