Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030012, Shanxi Province, China.
Department of Oral Medicine, The Fifth Clinical Medical College of Shanxi Medical University, 22 Shuangtasi Street, Taiyuan, 030012, Shanxi Province, China.
BMC Oral Health. 2021 Sep 27;21(1):479. doi: 10.1186/s12903-021-01850-3.
Periodontitis can lead to the destruction of periodontium and adversely influence the overall health, wellbeing, and quality of life. However, studies on the relationship between severe periodontitis and serum 25-hydroxyvitamin D [25(OH)D] are limited. This study is designed to explore the relationship between 25(OH)D and severe periodontitis.
A cross-section study of 2928 participants enrolled from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2014 was conducted. The periodontal examination was performed using a total oral periodontal examination program, and probe measurements were collected at six sites per tooth in NHANES. Severe periodontitis was characterized as: ≥ 2 interproximal sites with attachment loss (AL) ≥ 6 mm (not on the same tooth) and ≥ 1 interproximal site with probing depth (PD) ≥ 5 mm. Severe periodontitis and serum 25(OH)D were the dependent and independent variables, respectively. Univariate, multivariate, and subgroup analyses were performed to explore the relationship between severe periodontitis and serum 25(OH)D.
Among the 2928 participants, the average age of the population was 50 ± 13.71 years old, with 1425 (48.67%) males, 316 (10.79%) exhibited severe periodontitis. Serum 25(OH)D showed a significantly negative association with severe periodontitis after adjusting all variables (OR 0.75, 95% CI 0.63-0.89). In addition, severe periodontitis has a nonlinear relationship with serum 25(OH)D, whoes inflection point was 102 (nmol/L). On the left side of the inflection point (25(OH)D ≤ 102 nmol/L), the effect size was 0.98 and 95%CI was 0.98-0.99 (25(OH)D per 1 nmol/L increments). On the right side of the inflection point (25(OH)D > 102 nmol/L), the effect size was 0.99 and 95% CI was 0.98-1.01. The subgroup analysis showed pronounced changes in non-Hispanic white, alcohol consumption, diabetes, and health insurance.
Serum 25 (OH) D in relation to severe periodontitis is nonlinear in our study.When serum 25 (OH) D is less than 102 nmol/L, serum 25 (OH) D is negatively associated with severe periodontitis.
牙周炎可导致牙周组织破坏，并对整体健康、幸福感和生活质量产生不利影响。然而，关于重度牙周炎与血清 25-羟维生素 D [25(OH)D]之间关系的研究有限。本研究旨在探讨 25(OH)D 与重度牙周炎之间的关系。
采用横断面研究，选取 2013 年至 2014 年参加国家健康与营养调查（NHANES）的 2928 名参与者。牙周检查采用全口牙周检查方案，NHANES 每颗牙的 6 个位点采集探诊测量值。重度牙周炎的特征为：≥2 个近中部位附着丧失（AL）≥6mm（不在同一牙齿上）和≥1 个近中部位探诊深度（PD）≥5mm。重度牙周炎和血清 25(OH)D 分别为因变量和自变量。进行单变量、多变量和亚组分析，以探讨重度牙周炎与血清 25(OH)D 之间的关系。
在 2928 名参与者中，人群的平均年龄为 50±13.71 岁，其中男性 1425 人（48.67%），316 人（10.79%）患有重度牙周炎。调整所有变量后，血清 25(OH)D 与重度牙周炎呈显著负相关（OR 0.75，95%CI 0.63-0.89）。此外，重度牙周炎与血清 25(OH)D 呈非线性关系，拐点为 102（nmol/L）。在拐点左侧（25(OH)D≤102nmol/L），效应量为 0.98，95%CI 为 0.98-0.99（每增加 1nmol/L 的 25(OH)D）。在拐点右侧（25(OH)D＞102nmol/L），效应量为 0.99，95%CI 为 0.98-1.01。亚组分析显示，非西班牙裔白人、饮酒、糖尿病和医疗保险的变化显著。
在本研究中，血清 25（OH）D 与重度牙周炎的关系是非线性的。当血清 25（OH）D 低于 102nmol/L 时，血清 25（OH）D 与重度牙周炎呈负相关。
