Hunan Gynecological Tumor Clinical Research Center; Hunan Key Laboratory of Cancer Metabolism; Hunan Cancer Hospital, and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.
Public Service Platform of Tumor Organoids Technology, Changsha, China.
Immunology. 2024 Sep;173(1):14-32. doi: 10.1111/imm.13793. Epub 2024 Apr 15.
Despite progress in cancer immunotherapy, ovarian cancer (OC) prognosis continues to be disappointing. Recent studies have shed light on how not just tumour cells, but also the complex tumour microenvironment, contribute to this unfavourable outcome of OC immunotherapy. The complexities of the immune microenvironment categorize OC as a 'cold tumour'. Nonetheless, understanding the precise mechanisms through which the microenvironment influences the effectiveness of OC immunotherapy remains an ongoing scientific endeavour. This review primarily aims to dissect the inherent characteristics and behaviours of diverse cells within the immune microenvironment, along with an exploration into its reprogramming and metabolic changes. It is expected that these insights will elucidate the operational dynamics of the immune microenvironment in OC and lay a theoretical groundwork for improving the efficacy of immunotherapy in OC management.
尽管癌症免疫疗法取得了进展，但卵巢癌（OC）的预后仍然令人失望。最近的研究揭示了不仅肿瘤细胞，而且复杂的肿瘤微环境，如何导致 OC 免疫疗法的这种不利结果。免疫微环境的复杂性使 OC 成为一种“冷肿瘤”。尽管如此，了解微环境影响 OC 免疫疗法效果的确切机制仍然是一个持续的科学努力。本综述主要旨在剖析免疫微环境中不同细胞的固有特征和行为，以及对其重编程和代谢变化的探索。预计这些见解将阐明 OC 中免疫微环境的操作动态，并为改善 OC 管理中免疫疗法的疗效奠定理论基础。
