体外大鼠松果体中精氨酸血管加压素释放的神经递质调节

Neurotransmitter regulation of arginine vasotocin release from rat pineal glands in vitro.

作者信息

Sartin J L, Bruot B C, Orts R J

出版信息

Acta Endocrinol (Copenh). 1979 Jul;91(3):571-6. doi: 10.1530/acta.0.0910571.

DOI:10.1530/acta.0.0910571

Abstract

Studies were performed to determine the effects of neurotransmitters on arginine vasotocin (AVT) release in vitro. Rat pineal glands were incubated with 10(-8)M or 10(-6)M norepinephrine (NE), dopamine (DA), serotonin (5HT), and acetylcholine (ACH) for eight h after which the concentrations of AVT in the media were determined by radioimmunoassay. With the exception of ACH, none of the neurotransmitters had a significant effect on AVT release. ACH significantly (P less than 0.05) elevated AVT release in vitro at the 10(-6)M concentration but not at the 10(-8)M concentration. The data indicate that ACH may play a role in the regulation of rat pineal gland secretion of AVT in vitro.

摘要

开展了多项研究以确定神经递质对体外精氨酸血管加压素（AVT）释放的影响。将大鼠松果体与10⁻⁸M或10⁻⁶M去甲肾上腺素（NE）、多巴胺（DA）、5-羟色胺（5HT）及乙酰胆碱（ACH）一起孵育8小时，之后通过放射免疫测定法测定培养基中AVT的浓度。除ACH外，其他神经递质对AVT释放均无显著影响。ACH在10⁻⁶M浓度时可显著（P＜0.05）提高体外AVT释放，但在10⁻⁸M浓度时则无此作用。数据表明，ACH可能在体外对大鼠松果体AVT分泌的调节中发挥作用。