Patel Monak, Kumar Nitish, Bhukya Hussain, Dholakiya Bharatkumar Z, Naveen Togati
Department of Chemistry, Sardar Vallabhbhai National Institute of Technology Surat, Gujarat - 395 007, India.
Department of Biology, Indian Institute of Science Education and Research Tirupati, Andhra Pradesh - 517 507, India.
Org Biomol Chem. 2024 May 1;22(17):3386-3390. doi: 10.1039/d4ob00137k.
A copper-catalyzed direct -Csp-H thiocyanation of free anilines has been developed. This method employs stable and non-toxic ammonium thiocyanate as a thiocyanation source, and -butyl hydroperoxide as the oxidant, enabling the synthesis of -thiocyanated anilines with good yields and broad substrate tolerance. Hitherto, no reports have been found in the literature for the -thiocyanation of aromatic amines, making this reaction an important breakthrough in synthetic organic chemistry.
已开发出一种铜催化的游离苯胺直接Csp-H硫氰化反应。该方法使用稳定且无毒的硫氰酸铵作为硫氰化源，叔丁基过氧化氢作为氧化剂，能够以良好的产率和广泛的底物耐受性合成硫氰化苯胺。迄今为止，文献中尚未发现关于芳香胺硫氰化反应的报道，这使得该反应成为合成有机化学中的一项重要突破。
