Friedlander D H
N Z Med J. 1979 Aug 22;90(642):146-9.
A randomised open trial was carried out to test the efficacy and safety of Captopril and propranolol in 20 patients with mild and moderate essential hypertension. Mild and moderate was defined as a resting supine diastolic pressure of 100 to 120mmHg at the end of a placebo period. Patients were then randomised into Captopril (12) or propranolol (8) group. After a four-week dose ranging period, they were maintained on the treatment drug, or, if still uncontrolled, the other drug was added. The patients showed good overall blood pressure response to both treatment regimes. Three patients in the Captopril group developed a rash. The significance of the effectiveness in essential hypertension of a drug which acts to block the renin-angiotensin-aldosterone system is discussed.
进行了一项随机开放试验，以测试卡托普利和普萘洛尔对20例轻度和中度原发性高血压患者的疗效和安全性。轻度和中度定义为在安慰剂期结束时静息仰卧位舒张压为100至120mmHg。然后将患者随机分为卡托普利组（12例）或普萘洛尔组（8例）。在进行为期四周的剂量调整期后，他们继续使用治疗药物，或者，如果血压仍未得到控制，则加用另一种药物。患者对两种治疗方案均显示出良好的总体血压反应。卡托普利组有3名患者出现皮疹。文中讨论了一种作用于阻断肾素-血管紧张素-醛固酮系统的药物对原发性高血压的有效性意义。
