Laboratoire Toxlab, 7 rue Jacques Cartier, Paris 75018, France.
Laboratoire ChemTox, 3 Rue Gruninger, Illkirch-Graffenstaden 67400, France.
J Anal Toxicol. 2024 Jun 11;48(5):398-404. doi: 10.1093/jat/bkae021.
2-Fluorodeschloroketamine (2-FDCK) is a new psychoactive substance (NPS), close to the ketamine structure. Few cases of 2-FDCK intake are described in the forensic literature, especially concerning death cases. We report here a case of self-mutilation (Case 1) and two forensic deaths linked to 2-FDCK consumption. The second case involved a man found dead in the street, having been stabbed. The third case was a man found dead following a suspected overdose and in an advanced state of putrefaction. For all three cases, biological fluids such as blood and urine were analyzed, as was hair for the two fatal cases. The aim of this study was to identify and quantify 2-FDCK and its main metabolites in different matrices. Biological fluids and hair were analyzed by liquid chromatography coupled with tandem mass spectrometry after decontamination and extraction. Seized products were analyzed by gas chromatography-mass spectrometry and assayed, when possible, by ultra-performance liquid chromatography with diode-array detection. 2-FDCK was detected and quantified in the peripheral blood of Cases 1, 2 and 3 (457, 758 and 5885 µg/L, respectively), as were its main metabolites nor-2-FDCK, dihydro-nor-2-FDCK and dihydro-2-FDCK. In the 1 cm long hair of Cases 2 and 3, 2-FDCK was also detected (approximately 4149 and 79824 pg/mg, respectively). Deschloroketamine (DCK) was found in the biological fluids of Cases 1, 2 and 3 (10, 8 and 350 µg/L, respectively), as well as in hair of Cases 2 and 3 (65 and around 8119 pg/mg, respectively). In Case 3, as a small bag containing DCK powder was seized from his home, we can assume that DCK was taken. On the contrary, to our knowledge, it has not been established that Case 2 took DCK alone, so we can assume that it may be the first case to report DCK from 2-FDCK metabolism in fluids as well as in hair.
2-氟氯胺酮（2-FDCK）是一种新的精神活性物质（NPS），与氯胺酮结构相近。法医文献中描述的 2-FDCK 摄入病例较少，特别是涉及死亡的病例。我们在此报告了 1 例自残（病例 1）和 2 例与 2-FDCK 消费有关的法医死亡案例。第二例涉及一名在街上被发现死亡的男子，他被刺伤。第三例是一名男子在疑似过量用药并处于高度腐烂状态下死亡。对于所有三个案例，均分析了血液和尿液等生物体液，以及两例致命案例的头发。本研究的目的是在不同基质中鉴定和定量 2-FDCK 及其主要代谢物。通过液质联用技术对经过去污和提取的生物体液和头发进行分析。通过气相色谱-质谱联用技术对缴获的产品进行分析，并在可能的情况下通过二极管阵列检测超高效液相色谱进行分析。在病例 1、2 和 3 的外周血中均检测到并定量了 2-FDCK 及其主要代谢物去甲-2-FDCK、二氢去甲-2-FDCK 和二氢-2-FDCK（分别为 457、758 和 5885μg/L）。在病例 2 和 3 的 1cm 长头发中也检测到了 2-FDCK（分别约为 4149 和 79824pg/mg）。在病例 1、2 和 3 的生物体液中也发现了去氯氯胺酮（DCK）（分别为 10、8 和 350μg/L），以及病例 2 和 3 的头发中（分别为 65 和约 8119pg/mg）。在病例 3 中，从其家中缴获了一个装有 DCK 粉末的小袋子，我们可以假设 DCK 是被摄入的。相反，据我们所知，尚未确定病例 2 单独服用了 DCK，因此我们可以假设这是首例报告 2-FDCK 代谢产物在液体和头发中均产生 DCK 的案例。
