[神经退行性痴呆患者中新冠病毒病的病死率]
[Case fatality of COVID-19 in patients with neurodegenerative dementia].
作者信息
Reyes-Bueno J A, Mena-Vázquez N, Ojea-Ortega T, Gonzalez-Sotomayor M M, Cabezudo-Garcia P, Ciano-Petersen N L, Pons-Pons G, Castro-Sánchez M V, Serrano-Castro P J
机构信息
Unidad de Gestión Clínica de Neurociencias, Servicio de Neurología, Hospital Regional Universitario de Málaga, Málaga, España.
Unidad de Gestión Clínica de Reumatología, Hospital Regional Universitario de Málaga, Málaga, España.
出版信息
Neurologia. 2020 Nov-Dec;35(9):639-645. doi: 10.1016/j.nrl.2020.07.005. Epub 2020 Jul 28.
INTRODUCTION
The elderly population is the group most threatened by COVID-19, with the highest mortality rates. This study aims to analyse the case fatality of COVID-19 in a cohort of patients with degenerative dementia.
METHODS
We conducted a descriptive case-control study of a sample of patients diagnosed with primary neurodegenerative dementia.
RESULTS
Twenty-four of the 88 patients with COVID-19 included in the study died: 10/23 (43.4%) patients diagnosed with dementia and 14/65 (21.5%) controls; this difference was statistically significant.
DISCUSSION
Our results suggest that case fatality of COVID-19 is significantly higher among patients with primary degenerative dementia than in other patients with similar mean ages and comorbidities.
引言
老年人群是受新冠病毒肺炎（COVID-19）威胁最大的群体，死亡率最高。本研究旨在分析一组患有退行性痴呆的患者中COVID-19的病死率。
方法
我们对一组被诊断为原发性神经退行性痴呆的患者样本进行了描述性病例对照研究。
结果
该研究纳入的88例COVID-19患者中有24例死亡：23例被诊断为痴呆的患者中有10例（43.4%）死亡，65例对照中有14例（21.5%）死亡；这种差异具有统计学意义。
讨论
我们的结果表明，原发性退行性痴呆患者中COVID-19的病死率显著高于其他平均年龄和合并症相似的患者。
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