Lindahl Hannes, Smith C I Edvard, Bergman Peter
Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden.
Immunodeficiency Unit, Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
Clin Immunol Commun. 2021 Dec;1:20-24. doi: 10.1016/j.clicom.2021.08.003. Epub 2021 Oct 8.
Antibody deficiencies constitute the majority of primary immunodeficiencies in adults. These patients have a well-established increased risk of bacterial infections but there is a lack of knowledge regarding the relative risks upon contracting COVID-19. In this monocentric study the disease course of COVID-19 in 1 patient with Good's syndrome and in 13 patients with common variable immunodeficiency (CVID) is described. The severity of disease ranged from very mild to severe. Several patients required hospitalization and immunomodulatory treatment but all survived. Although viral infections are not a typical feature of humoral immunodeficiencies we recommend that vigilance is increased in the management of patients with Good's syndrome and CVID during the COVID-19 pandemic.
抗体缺陷是成人原发性免疫缺陷的主要类型。这些患者发生细菌感染的风险已明确增加，但对于感染新型冠状病毒肺炎（COVID-19）后的相对风险尚缺乏了解。在这项单中心研究中，描述了1例Good综合征患者和13例常见变异型免疫缺陷（CVID）患者的COVID-19病程。疾病严重程度从非常轻微到严重不等。数名患者需要住院治疗和免疫调节治疗，但均存活。尽管病毒感染并非体液免疫缺陷的典型特征，但我们建议在COVID-19大流行期间，对Good综合征和CVID患者的管理应提高警惕。
