Graduate School, Anhui University of CM, Hefei 230038, China.
Third Department of Geriatric Diseases, Anhui Provincial Hospital of Acupuncture and Moxibustion, Hefei 230061.
Zhongguo Zhen Jiu. 2024 Apr 12;44(4):469-478. doi: 10.13703/j.0255-2930.20230721-k0003.
The research history, hot spots and frontier trends of acupuncture and moxibustion for Alzheimer's disease (AD) were explored using knowledge graph technology. The articles on acupuncture and moxibustion for AD were searched from 6 databases, i.e. CNKI, VIP, Wanfang, SinoMed, Pubmed and Web of Science, from January 1st, 1993 to January 1st, 2023. Using CiteSpace6.2.R2 Advance and VOSviewer V1.6.19 softwares, the knowledge map was graphed and the visual analysis was performed. A total of 1 228 Chinese and 309 English articles were included. The high-frequency keywords were generally divided into the keywords of clinical diseases (AD, dementia), those of therapeutic methods (electroacupuncture, acupuncture-moxibustion and acupuncture) and those of mechanism study (β-amyloid, mice). Thirteen keyword clusters were formed among the articles of Chinese version, e.g. acupuncture-moxibustion, dementia, acupuncture and electroacupuncture; and 8 clusters were obtained among English articles, e.g. electroacupuncture, drug therapy and hippocampus. The high-frequency keywords of acupoints included Baihui (GV 20), Dazhui (GV 14), Yintang (GV 24), Zusanli (ST 36), Fenglong (ST 40), etc. Six clusters of "acupuncture techniques → acupoints" were obtained for the treatment of AD with acupuncture and moxibustion. The therapeutic methods and modes of AD with acupuncture and moxibustion are constantly progressed, the development of clinical research tends to the evaluation of novel therapeutic mode and clinical effect, and the mechanism of acupuncture and moxibustion for the effect on AD are more deeply explored. Among the various therapeutic methods, acupuncture-moxibustion, acupuncture and electroacupuncture have been early predominant; while, many novel methods are gradually displayed later, such as music electroacupuncture and hydro-acupuncture. In recent 30 years, among Chinese and English articles for the studies of AD treated with acupuncture and moxibustion, the theme of them focuses on the two aspects, the observation of clinical effect and the mechanism research. It is found that the clinical therapeutic methods have been gradually improved and the mechanism exploration been deepened.
采用知识图谱技术探讨了针灸治疗阿尔茨海默病（AD）的研究历史、热点和前沿趋势。从 1993 年 1 月 1 日至 2023 年 1 月 1 日，从 6 个数据库（CNKI、VIP、万方、SinoMed、PubMed 和 Web of Science）中检索针灸治疗 AD 的文献。使用 CiteSpace6.2.R2 Advance 和 VOSviewer V1.6.19 软件绘制知识图谱并进行可视化分析。共纳入 1228 篇中文文献和 309 篇英文文献。高频关键词一般分为临床疾病（AD、痴呆）治疗方法（电针、针灸、针刺）和机制研究（β-淀粉样蛋白、小鼠）的关键词。中文文献形成了 13 个关键词群，如针灸、痴呆、针灸、电针；英文文献形成了 8 个关键词群，如电针、药物治疗、海马。穴位高频关键词包括百会（GV20）、大椎（GV14）、印堂（GV24）、足三里（ST36）、丰隆（ST40）等。针刺治疗 AD 获得了 6 个“针刺技术→穴位”的聚类。针灸治疗 AD 的方法和模式不断发展，临床研究的发展趋势倾向于评估新的治疗模式和临床效果，针灸治疗 AD 的机制也得到了更深入的探索。在各种治疗方法中，针灸、针刺和电针一直处于早期主导地位，而许多新的方法则逐渐显现，如音乐电针和水针。近 30 年来，在针灸治疗 AD 的中文和英文文献中，主题集中在观察临床疗效和机制研究两个方面。发现临床治疗方法逐渐完善，机制探索不断深入。
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