中国东部矽肺矿工潜伏性结核感染及感染相关危险因素
Latent tuberculosis infection and infection-associated risk factors for miner workers with silicosis in eastern China.
机构信息
School of Public Health, Nanjing Medical University, Nanjing, China.
Department of Chronic Communicable Disease, Center for Disease Control and Prevention of Jiangsu Province, Nanjing, China.
出版信息
BMC Pulm Med. 2024 Apr 15;24(1):177. doi: 10.1186/s12890-024-02985-z.
OBJECTIVES
Silicosis people are at high risk of developing pulmonary tuberculosis. Whether silica exposure increases the likelihood of latent tuberculosis infection (LTBI) was not well understood, and potential factors involved in LTBI risk among silicosis people were not evaluated before. Thus, LTBI among silicosis people and potential risk factors for LTBI among silicosis people were evaluated in this study.
METHODS
A cross-sectional study was undertaken for 130 miner workers with silicosis. The QFT-GIT was performed for LTBI detection.
RESULTS
The LTBI was high to 31.6% (36/114) for silicosis participants, and 13.1% (13/99) had a history of tuberculosis. Drinking was associated with LTBI risk (OR = 6.92, 95%CI, 1.47-32.66, P = 0.015). Meanwhile, tunneling work was associated with an increased risk of LTBI compared with other mining occupations (OR = 3.91,95%CI,1.20-12.70, P = 0.024).
CONCLUSIONS
The LTBI rate of silicosis participants was high and more than 10% had a history of tuberculosis. Drinking alcohol and tunneling were independent risk factors for LTBI in silicosis participants.
目的
矽肺患者患肺结核的风险较高。然而，矽尘暴露是否会增加潜伏性结核感染（LTBI）的可能性尚不清楚，矽肺患者发生 LTBI 的潜在危险因素也尚未得到评估。因此，本研究评估了矽肺患者中的 LTBI 及其潜在危险因素。
方法
对 130 名矽肺矿工进行了横断面研究。采用 QFT-GIT 检测 LTBI。
结果
矽肺患者的 LTBI 率高达 31.6%（36/114），其中 13.1%（13/99）有结核病病史。饮酒与 LTBI 风险相关（OR=6.92，95%CI，1.47-32.66，P=0.015）。同时，与其他采矿职业相比，隧道工作与 LTBI 风险增加相关（OR=3.91，95%CI，1.20-12.70，P=0.024）。
结论
矽肺患者的 LTBI 率较高，超过 10%的患者有结核病病史。饮酒和隧道工作是矽肺患者发生 LTBI 的独立危险因素。
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