Widjaja Nur Aisiyah, Hamida Azizah, Purnomo Marisa Tulus, Satjadibrata Azarina, Sari Putri Permata, Handini Laksmi Suci, Novi Theresia, Hanindita Meta Herdiana, Irawan Roedi
Child Health Department, Airlangga/Dr.Soetomo General Academic Teaching Hospital, Surabaya, Indonesia.
Child Health, Husada Utama Hospital, Surabaya, Indonesia.
Heliyon. 2024 Apr 3;10(7):e28834. doi: 10.1016/j.heliyon.2024.e28834. eCollection 2024 Apr 15.
High-calorie formulas have been used to promote catch-up growth in undernourished children. The level of insulin-like growth factor 1 (IGF-1) is closely related to weight and nutritional intake, whereas low a total lymphocyte count (TLC) is associated with impaired immune system function in undernourished children. This study was conducted to investigate the effect of high-calorie formula as an intervention on weight, height increment, IGF-1 and TLC in children with growth faltering or undernutrition. A quasi-experimental study with pre- and post-design was conducted in the outpatient clinic of a private hospital during October 2021-July 2022 on children with growth failure and underlying infection. For 90 days, subjects were given a high-calorie formula. An enzyme-linked immunosorbent assay was then conducted to measure IGF-1, followed by a complete blood count examination. Subjects were divided into two groups based on age: Group 1 (12-24 months) and Group 2 (>24-60 months). There was a significant increment in body weight and body length/height after intervention but no significant difference between the groups. The increment of body length/height after intervention was greater in Group 1 than Group 2 ( = 0.000) and reduced the incidence of stunted/severely stunted and wasted/severely wasted children ( > 0.05). IGF-1 increased after the intervention but with no significant difference (1.42 ± 8.31 ng/ml; = 0.144). There was a significant reduction in TLC after the intervention (1194.34 + 4400.34 cells/mm; = 0.002) that was reduced in Group 1 and slightly increased in Group 2 ( = 0.003). Being underweight/severely underweight increased the risk of a low TLC by 27.658-fold but this risk was reduced by 25.904-fold after nutritional intervention. High-calorie formula intervention increases body weight and body length/height, reduces the incidence of underweight, stunted and wasted children and improves IGF-1 levels.
高热量配方已被用于促进营养不良儿童的追赶生长。胰岛素样生长因子1（IGF-1）水平与体重和营养摄入密切相关，而低总淋巴细胞计数（TLC）与营养不良儿童的免疫系统功能受损有关。本研究旨在调查高热量配方作为一种干预措施对生长发育迟缓或营养不良儿童的体重、身高增长、IGF-1和TLC的影响。2021年10月至2022年7月期间，在一家私立医院的门诊对生长发育不良且有潜在感染的儿童进行了一项前后设计的准实验研究。在90天内，给受试者服用高热量配方。然后进行酶联免疫吸附测定以测量IGF-1，随后进行全血细胞计数检查。受试者按年龄分为两组：第1组（12至24个月）和第2组（大于24至60个月）。干预后体重和身长/身高有显著增加，但两组之间无显著差异。干预后第1组的身长/身高增加幅度大于第2组（P = 0.000），并降低了发育迟缓/严重发育迟缓以及消瘦/严重消瘦儿童的发生率（P>0.05）。干预后IGF-1升高，但无显著差异（1.42±8.31 ng/ml；P = 0.144）。干预后TLC有显著降低（1194.34 + 4400.34个细胞/mm；P = 0.002），第1组降低，第2组略有升高（P = 0.003）。体重不足/严重体重不足使TLC降低的风险增加27.658倍，但营养干预后该风险降低了25.904倍。高热量配方干预可增加体重和身长/身高，降低体重不足、发育迟缓和消瘦儿童的发生率，并提高IGF-1水平。
