Cai Chao, Li Wanqian, Zhang Xiyue, Cheng Biao, Chen Shixuan, Zhang Yi
Department of Burn and Plastic Surgery, Affiliated Hospital of Nantong University, Nantong, China.
Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China.
Adv Wound Care (New Rochelle). 2025 Jun;14(6):295-322. doi: 10.1089/wound.2024.0024. Epub 2024 Jul 25.
Acute wounds such as severe burns and chronic wounds like diabetic ulcers present a significant threat to human health. Wound dressings made from natural polymers offer inherent properties that effectively enhance wound healing outcomes and reduce healing time. Numerous innovative hydrogels are being developed and translated to the clinic to successfully treat various wound types. This underscores the substantial potential of hydrogels in the future wound care market. Economically, annual sales of wound care products are projected to reach $15-22 billion by 2024. While chitosan-, cellulose-, and collagen-based hydrogel dressings are currently commercially available, scaling-up and manufacturing hydrogels for commercial products remain a challenging process. In addition, ensuring the sterility and stability of the chemical or biological components comprising the hydrogel is a critical consideration. In light of the persistent increase in wound fatalities and the resulting economic and social impacts, as well as the importance of educating the public about dietary health and disease, there should be increased investment in new wound care dressings, particularly hydrogels derived from natural products. With numerous researchers dedicated to advancing preclinical hydrogels, the future holds promise for more innovative and more personalized hydrogel wound dressings.
严重烧伤等急性伤口以及糖尿病溃疡等慢性伤口对人类健康构成重大威胁。由天然聚合物制成的伤口敷料具有固有的特性，能有效改善伤口愈合效果并缩短愈合时间。目前正在研发多种创新水凝胶并将其转化应用于临床，以成功治疗各种类型的伤口。这凸显了水凝胶在未来伤口护理市场的巨大潜力。在经济方面，预计到2024年伤口护理产品的年销售额将达到150亿至220亿美元。虽然基于壳聚糖、纤维素和胶原蛋白的水凝胶敷料目前已在市场上销售，但扩大水凝胶的生产规模以用于商业产品仍然是一个具有挑战性的过程。此外，确保构成水凝胶的化学或生物成分的无菌性和稳定性是一个关键考量因素。鉴于伤口致死率持续上升及其带来的经济和社会影响，以及对公众进行饮食健康和疾病教育的重要性，应增加对新型伤口护理敷料的投资，特别是源自天然产品的水凝胶。随着众多研究人员致力于推进临床前水凝胶的研究，未来有望出现更多创新且更具个性化的水凝胶伤口敷料。
