Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape 5700, South Africa.
Int J Mol Sci. 2020 Dec 18;21(24):9656. doi: 10.3390/ijms21249656.
Wound management remains a challenge worldwide, although there are several developed wound dressing materials for the management of acute and chronic wounds. The wound dressings that are currently used include hydrogels, films, wafers, nanofibers, foams, topical formulations, transdermal patches, sponges, and bandages. Hydrogels exhibit unique features which make them suitable wound dressings such as providing a moist environment for wound healing, exhibiting high moisture content, or creating a barrier against bacterial infections, and are suitable for the management of exuding and granulating wounds. Biopolymers have been utilized for their development due to their non-toxic, biodegradable, and biocompatible properties. Hydrogels have been prepared from biopolymers such as cellulose and chitosan by crosslinking with selected synthetic polymers resulting in improved mechanical, biological, and physicochemical properties. They were useful by accelerating wound re-epithelialization and also mimic skin structure, inducing skin regeneration. Loading antibacterial agents into them prevented bacterial invasion of wounds. This review article is focused on hydrogels formulated from two biopolymers-chitosan and cellulose-for improved wound management.
伤口管理仍然是一个全球性的挑战，尽管有几种已开发的伤口敷料材料可用于管理急性和慢性伤口。目前使用的伤口敷料包括水凝胶、薄膜、薄片、纳米纤维、泡沫、局部制剂、透皮贴剂、海绵和绷带。水凝胶具有独特的特性，使其成为合适的伤口敷料，例如为伤口愈合提供湿润的环境、具有高含水量或形成防止细菌感染的屏障，并且适用于处理渗出和肉芽伤口。由于其无毒、可生物降解和生物相容性，生物聚合物已被用于其开发。水凝胶已由纤维素和壳聚糖等生物聚合物通过与选定的合成聚合物交联制备而成，从而改善了机械、生物和物理化学性能。它们通过加速伤口再上皮化并模拟皮肤结构来促进皮肤再生，从而发挥作用。将抗菌剂加载到其中可以防止细菌侵入伤口。本文综述了由两种生物聚合物-壳聚糖和纤维素-为改善伤口管理而配制的水凝胶。
