Liu Xingxing, Wen Yi, Wang Xilei, Qi Yan, Zhou Wenhao, Tu Yijun, Lei Jiachuan, Cheng Hong, Yu Jianqing
Department of Pharmacy, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan, China.
Renmin Hospital, Wuhan University, Wuhan, China.
Nat Prod Res. 2024 Apr 16:1-9. doi: 10.1080/14786419.2024.2342002.
Two novel neolignans, piperkadsurenin A () and kadsurenin N (), along with six known neolignans () and two lignans () were isolated from the stems of (Choisy) Ohwi. Extensive spectroscopic data interpretation and ECD calculations were used to identify the structures of the new compounds and . Especially, compound represents the first example of neolignan with cyclopenta[]pyran framework. The anti-inflammatory efficacy of compounds was systematically assessed through NO production inhibitory assay. Compounds and significantly inhibited LPS-induced NO generation in RAW 264.7 cells, with IC values of 34.29 ± 0.82 and 47.5 ± 5.81 μM, respectively.
从海风藤（Piper kadsura (Choisy) Ohwi）茎中分离得到两个新的新木脂素，海风藤新素A（piperkadsurenin A）和海风藤新素N（kadsurenin N），以及六个已知新木脂素和两个木脂素。通过广泛的光谱数据分析和电子圆二色（ECD）计算确定了新化合物的结构。特别地，化合物代表了具有环戊[a]吡喃骨架的新木脂素的首个实例。通过一氧化氮（NO）生成抑制试验系统评估了化合物的抗炎功效。化合物和显著抑制脂多糖（LPS）诱导的RAW 264.7细胞中NO的生成，IC值分别为34.29±0.82和47.5±5.81μM。
