Han Ying Ying, Li Ji Yan, Guan Jia Lun, Liu Mei, Li Pei Yuan
Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Department of Gastroenterology, Wenchang People's Hospital, Wenchang, Hainan Province, China.
J Dig Dis. 2024 Mar;25(3):148-155. doi: 10.1111/1751-2980.13265. Epub 2024 Apr 16.
Increasing antibiotic resistance is the primary reason for treatment failure of Helicobacter pylori (H. pylori) infection. To enhance the eradication rate, minimize the development of secondary resistance, and alleviate the socioeconomic burden, it is crucial to select H. pylori-sensitive antibiotics carefully. Furazolidone has been used for H. pylori eradication in developing countries for decades due to its affordability and low resistance rate. Numerous studies have demonstrated that furazolidone-containing regimens are more efficacious than those containing other antibiotics, as both first- and second-line therapies, and are also well tolerated. However, utility of furazolidone is restricted or not optimal in certain countries due to its infrequent but potentially severe adverse effects. The decision to discontinue usage of furazolidone because of concerns regarding adverse effects may be misguided. Here we comprehensively reviewed the studies on furazolidone at different dosages and treatment durations for H. pylori eradication. Further research on the mechanisms of action and clinical trials of furazolidone are of great practical importance.
抗生素耐药性不断增加是幽门螺杆菌（H. pylori）感染治疗失败的主要原因。为提高根除率、尽量减少继发性耐药的发生并减轻社会经济负担，谨慎选择对H. pylori敏感的抗生素至关重要。由于价格低廉且耐药率低，呋喃唑酮在发展中国家已用于根除H. pylori数十年。大量研究表明，含呋喃唑酮的方案作为一线和二线治疗方案，比含其他抗生素的方案更有效，且耐受性良好。然而，由于其不良反应虽不常见但可能严重，呋喃唑酮在某些国家的使用受到限制或不理想。因担心不良反应而决定停用呋喃唑酮可能是错误的。在此，我们全面回顾了关于不同剂量和治疗疗程的呋喃唑酮用于根除H. pylori的研究。对呋喃唑酮作用机制的进一步研究和临床试验具有重要的实际意义。
